Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.47 |
| ▸ | GAA | P10253 | 5/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.39 |
| ▸ | LMNA | P02545 | 4/20 | 0.39 |
| ▸ | RAB9A | P51151 | 4/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | CASP7 | P55210 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2061060 | 0.98 | MAPT (0.44) | MAPTGAAKDM4ESMN1; SMN2LMNA | |
| SCHEMBL3982958 | 0.85 | MAPT (0.40) | MAPTGAAKDM4ESMN1; SMN2LMNA | |
| SCHEMBL29989368 | 0.85 | MAPT (0.40) | MAPTGAAKDM4ESMN1; SMN2LMNA | |
| SCHEMBL6291296 | 0.85 | MAPT (0.40) | MAPTGAAKDM4ESMN1; SMN2LMNA | |
| SCHEMBL17925963 | 0.81 | — | — | |
| SCHEMBL42805 | 0.77 | CA12 (0.48) | MAPTGAAKDM4ESMN1; SMN2LMNA | |
| SCHEMBL29779691 | 0.77 | CA12 (0.48) | MAPTGAAKDM4ESMN1; SMN2LMNA | |
| SCHEMBL264473 | 0.77 | ADRA2A (0.47) | MAPTGAAKDM4ESMN1; SMN2LMNA | |
| SCHEMBL19678691 | 0.75 | LMNA (0.60) | MAPTGAAKDM4ESMN1; SMN2LMNA | |
| SCHEMBL21765305 | 0.75 | HSD17B10 (0.48) | MAPTGAAKDM4ESMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022268026-A1 | 1,2,4-TRIAZOLE COMPOUNDS AS AXL INHIBITORS | 南京正大天晴制药有限公司 | 2022-12-29 | — | — | WO | disclosed |