Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | EDNRA | P25101 | 12/20 | 0.35 |
| ▸ | EDNRB | P24530 | 7/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | NFE2L2 | Q16236 | 3/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30743760 | 1.00 | ALDH1A1 (0.42) | ALDH1A1EDNRAEDNRBLMNAMAPK1 | |
| SCHEMBL24823855 | 0.93 | EDNRA (0.38) | ALDH1A1EDNRAEDNRBNFE2L2TP53 | |
| SCHEMBL30743763 | 0.93 | EDNRA (0.38) | ALDH1A1EDNRAEDNRBNFE2L2TP53 | |
| SCHEMBL24822217 | 0.86 | ALDH1A1 (0.39) | ALDH1A1EDNRAEDNRBLMNAMAPK1 | |
| SCHEMBL24823033 | 0.82 | NFE2L2 (0.35) | EDNRAEDNRBNFE2L2 | |
| SCHEMBL30743769 | 0.82 | ALDH1A1 (0.35) | ALDH1A1EDNRAEDNRB | |
| SCHEMBL27207897 | 0.82 | ALDH1A1 (0.35) | ALDH1A1EDNRAEDNRB | |
| SCHEMBL24823054 | 0.80 | NFE2L2 (0.35) | EDNRAEDNRBNFE2L2TP53MAPT | |
| SCHEMBL24822821 | 0.78 | MAPT (0.35) | EDNRAEDNRBTP53MAPT | |
| SCHEMBL4632365 | 0.75 | EDNRA (0.55) | EDNRAEDNRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4361146-A1 | COMPOUND, ENDOTHELIN-A RECEPTOR ANTAGONIST, AND PHARMACEUTICAL COMPOSITION | Alchemedicine, Inc. (JP) | 2024-05-01 | — | — | EP | disclosed |
| CN-117255791-A | Compounds, endothelin A receptor antagonists and pharmaceutical compositions | 亚克医药株式会社 | 2023-12-19 | — | — | CN | disclosed |
| WO-2022270487-A1 | COMPOUND, ENDOTHELIN-A RECEPTOR ANTAGONIST, AND PHARMACEUTICAL COMPOSITION | 株式会社アークメディスン | 2022-12-29 | — | — | WO | disclosed |