Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.51 |
| ▸ | ABL1 | P00519 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 6/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | HPGD | P15428 | 4/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.47 |
| ▸ | GLA | P06280 | 2/20 | 0.47 |
| ▸ | CASP1 | P29466 | 1/20 | 0.47 |
| ▸ | CASP7 | P55210 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | CFTR | P13569 | 5/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26829405 | 0.88 | ALDH1A1 (0.41) | KDM4EALDH1A1ABL1GAAMAPT | |
| SCHEMBL30311124 | 0.79 | KDM4E (0.56) | KDM4EALDH1A1ABL1GAAMAPT | |
| SCHEMBL1506603 | 0.79 | KDM4E (0.56) | KDM4EALDH1A1ABL1GAAMAPT | |
| SCHEMBL2478058 | 0.79 | KDM4E (0.56) | KDM4EALDH1A1ABL1GAAMAPT | |
| SCHEMBL30310840 | 0.78 | KDM4E (0.57) | KDM4EALDH1A1ABL1GAAMAPT | |
| SCHEMBL2479419 | 0.78 | KDM4E (0.57) | KDM4EALDH1A1ABL1GAAMAPT | |
| SCHEMBL21468462 | 0.78 | KDM4E (0.54) | KDM4EALDH1A1ABL1GAAMAPT | |
| SCHEMBL4758833 | 0.78 | KDM4E (0.73) | KDM4EALDH1A1ABL1GAAMAPT | |
| SCHEMBL5692887 | 0.76 | KDM4E (0.70) | KDM4EALDH1A1ABL1GAAMAPT | |
| SCHEMBL2479188 | 0.75 | KDM4E (0.47) | KDM4EALDH1A1ABL1GAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022267930-A1 | TRICYCLIC COMPOUND, PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF | 中国医药研究开发中心有限公司 | 2022-12-29 | — | — | WO | disclosed |