Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.39 |
| ▸ | SLC9A1 | P19634 | 2/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 7/20 | 0.33 |
| ▸ | TDP2 | O95551 | 3/20 | 0.33 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.33 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.33 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.32 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.32 |
| ▸ | CHRM3 | P20309 | 4/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.32 |
| ▸ | PGR | P06401 | 2/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.31 |
| ▸ | LCK | P06239 | 1/20 | 0.31 |
| ▸ | SRC | P12931 | 1/20 | 0.31 |
| ▸ | PRKACA | P17612 | 1/20 | 0.31 |
| ▸ | PRKACG | P22612 | 1/20 | 0.31 |
| ▸ | PRKACB | P22694 | 1/20 | 0.31 |
| ▸ | KDR | P35968 | 1/20 | 0.31 |
| ▸ | FLT3 | P36888 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2480657 | 0.88 | CHRM1 (0.34) | SLC9A1CHRM1TDP2HSD17B1HSD17B2 | |
| SCHEMBL2482779 | 0.81 | HCRTR1 (0.35) | BRD4TDP2HCRTR1HCRTR2PGR | |
| SCHEMBL2479703 | 0.81 | CA12 (0.34) | SLC9A1CHRM1TDP2CHRM3CHRM2 | |
| SCHEMBL421601 | 0.76 | MAPK14 (0.40) | BRD4CREBBPSLC9A1TDP2HCRTR1 | |
| SCHEMBL10109878 | 0.68 | MAPK14 (0.46) | SLC9A1HSD17B1HSD17B2 | |
| SCHEMBL10109877 | 0.66 | MAPK14 (0.39) | SLC9A1TDP2MAPK1 | |
| SCHEMBL422068 | 0.65 | MAPK14 (0.50) | SLC9A1KDRGSK3AGSK3B | |
| SCHEMBL424176 | 0.65 | MAPK14 (0.37) | HCRTR1HCRTR2 | |
| SCHEMBL423833 | 0.65 | MAPK14 (0.37) | HCRTR1HCRTR2 | |
| SCHEMBL424281 | 0.64 | MAPK14 (0.42) | BRD4CREBBPSLC9A1CHRM1TDP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2376482-A1 | SUBSTITUTED (THIOPHENYL-CARBONYL)IMIDAZOLIDINONES, AND USE THEREOF | AiCuris GmbH & Co. KG (DE) | 2011-10-19 | — | — | EP | disclosed |
| WO-2010075962-A1 | SUBSTITUTED (THIOPHENYL-CARBONYL)IMIDAZOLIDINONES, AND USE THEREOF | AICURIS GMBH & CO. KG (DE) | 2010-07-08 | — | — | WO | disclosed |