Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 6/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 5/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | ARNT | P27540 | 3/20 | 0.31 |
| ▸ | EPAS1 | Q99814 | 3/20 | 0.31 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.31 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.31 |
| ▸ | CLK1 | P49759 | 1/20 | 0.31 |
| ▸ | CLK2 | P49760 | 1/20 | 0.31 |
| ▸ | CLK3 | P49761 | 1/20 | 0.31 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.31 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.31 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.31 |
| ▸ | TDP2 | O95551 | 2/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2482585 | 0.88 | BRD4 (0.39) | CHRM1CHRM3CHRM2HSD17B1HSD17B2 | |
| SCHEMBL2479703 | 0.82 | CA12 (0.34) | CHRM1CHRM3CHRM2CLK1CLK2 | |
| SCHEMBL2482779 | 0.80 | HCRTR1 (0.35) | HSP90AA1HSP90AB1TDP2NPC1POLB | |
| SCHEMBL422736 | 0.75 | MAPK14 (0.41) | CHRM1CHRM3CHRM2NPC1RAB9A | |
| SCHEMBL419608 | 0.68 | PTGDR2 (0.43) | — | |
| SCHEMBL426459 | 0.67 | MAPK14 (0.39) | — | |
| SCHEMBL421761 | 0.67 | PGR (0.39) | CHRM1CHRM3CHRM2 | |
| SCHEMBL10109878 | 0.66 | MAPK14 (0.46) | HSD17B1HSD17B2SLC9A1NPC1POLB | |
| SCHEMBL422068 | 0.66 | MAPK14 (0.50) | SLC9A1 | |
| SCHEMBL424281 | 0.65 | MAPK14 (0.42) | CHRM1CHRM3CHRM2ARNTEPAS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2376482-A1 | SUBSTITUTED (THIOPHENYL-CARBONYL)IMIDAZOLIDINONES, AND USE THEREOF | AiCuris GmbH & Co. KG (DE) | 2011-10-19 | — | — | EP | disclosed |
| WO-2010075962-A1 | SUBSTITUTED (THIOPHENYL-CARBONYL)IMIDAZOLIDINONES, AND USE THEREOF | AICURIS GMBH & CO. KG (DE) | 2010-07-08 | — | — | WO | disclosed |