Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.58 |
| ▸ | IGF1R | P08069 | 2/20 | 0.35 |
| ▸ | ACHE | P22303 | 3/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.34 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.34 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.33 |
| ▸ | PTGES | O14684 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.33 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.32 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.31 |
| ▸ | HTR6 | P50406 | 1/20 | 0.31 |
| ▸ | BRAF | P15056 | 1/20 | 0.31 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.31 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.31 |
| ▸ | KIT | P10721 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2448023 | 0.91 | TRPM8 (0.47) | TRPM8IGF1RACHEMCL1KAT2B | |
| SCHEMBL19580143 | 0.90 | TRPM8 (0.60) | TRPM8IGF1RPTGESKDM4EADORA2B | |
| SCHEMBL2483336 | 0.89 | TRPM8 (0.63) | TRPM8PTGESCRHR1KDM4EADORA2B | |
| SCHEMBL19580157 | 0.87 | TRPM8 (0.57) | TRPM8IGF1RACHE | |
| SCHEMBL15753949 | 0.87 | TRPM8 (0.60) | TRPM8PTGESKDM4E | |
| SCHEMBL2486272 | 0.86 | TRPM8 (0.56) | TRPM8HRH4 | |
| SCHEMBL2445898 | 0.86 | TRPM8 (0.74) | TRPM8PTGESKDM4E | |
| SCHEMBL2482537 | 0.86 | TRPM8 (0.59) | TRPM8IGF1RPTGESKDM4E | |
| SCHEMBL2482533 | 0.86 | TRPM8 (0.59) | TRPM8PTGESKDM4E | |
| Potassium SCHEMBL2445679 | 0.85 | TRPM8 (0.73) | TRPM8PTGESKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2542552-B1 | SUBSTITUTED AZA-BICYCLIC IMIDAZOLE DERIVATIVES USEFUL AS TRPM8 RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2017-11-15 | — | — | EP | disclosed |
| EP-2542552-A1 | SUBSTITUTED AZA-BICYCLIC IMIDAZOLE DERIVATIVES USEFUL AS TRPM8 RECEPTOR MODULATORS | Janssen Pharmaceutica, N.V. (BE) | 2013-01-09 | — | — | EP | disclosed |
| WO-2011109587-A1 | SUBSTITUTED AZA-BICYCLIC IMIDAZOLE DERIVATIVES USEFUL AS TRPM8 RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2011-09-09 | — | — | WO | disclosed |