Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 4/20 | 0.38 |
| ▸ | HTT | P42858 | 5/20 | 0.32 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.32 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.32 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | GFER | P55789 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 2/20 | 0.31 |
| ▸ | JAK1 | P23458 | 1/20 | 0.31 |
| ▸ | AURKA | O14965 | 1/20 | 0.31 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.31 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.31 |
| ▸ | PAK4 | O96013 | 1/20 | 0.31 |
| ▸ | ABL1 | P00519 | 1/20 | 0.31 |
| ▸ | LCK | P06239 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL249625 | 0.87 | PIK3CD (0.35) | MAP4K4HTTPIK3CGPIK3CDPIK3CA | |
| SCHEMBL246483 | 0.87 | MAP4K4 (0.38) | MAP4K4HTTPIK3CGPIK3CDPIK3CA | |
| SCHEMBL249677 | 0.85 | PIK3CD (0.36) | MAP4K4HTTPIK3CGPIK3CDPIK3CA | |
| SCHEMBL249593 | 0.85 | HTT (0.34) | MAP4K4HTTPIK3CGPIK3CDPIK3CA | |
| SCHEMBL250361 | 0.84 | PIK3CD (0.38) | MAP4K4HTTPIK3CGPIK3CDPIK3CA | |
| SCHEMBL249789 | 0.84 | MAP4K4 (0.35) | MAP4K4HTTPIK3CGPIK3CDPIK3CA | |
| SCHEMBL249910 | 0.84 | PIK3CD (0.37) | MAP4K4HTTPIK3CGPIK3CDPIK3CA | |
| SCHEMBL248495 | 0.83 | PIK3CD (0.38) | MAP4K4HTTPIK3CGPIK3CDPIK3CA | |
| SCHEMBL249334 | 0.83 | IP6K1 (0.39) | HTTPIK3CGPIK3CDPIK3CAPIK3CB | |
| SCHEMBL248515 | 0.82 | HTT (0.34) | MAP4K4HTTPIK3CGPIK3CDPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2588469-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE AS INHIBITORS OF PI3K ACTIVITY | Amgen Inc. (US) | 2013-05-08 | — | — | EP | disclosed |
| WO-2012003271-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE AS INHIBITORS OF PI3K ACTIVITY | AMGEN INC. (US) | 2012-01-05 | — | — | WO | disclosed |