SCHEMBL2483134

SCHEMBL2483134

C[CH]Cc1ccc(OC)c(F)c1

nearest known ligand 0.51

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.49
PPARG P37231 1/20 0.49
PPARD Q03181 1/20 0.49
PPARA Q07869 1/20 0.49
CYP17A1 P05093 1/20 0.46
TUBB1 Q9H4B7 3/20 0.46
DBH P09172 1/20 0.46
HTT P42858 2/20 0.44
KDM4E B2RXH2 1/20 0.44
MITF O75030 1/20 0.44
NPC1 O15118 1/20 0.44
RAB9A P51151 1/20 0.44
SMN1; SMN2 Q16637 1/20 0.44
LMNA P02545 1/20 0.43
L3MBTL1 Q9Y468 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL874054 0.85 ALDH1A1 (0.49) ALDH1A1PPARGPPARDPPARACYP17A1
SCHEMBL27613147 0.85 ALDH1A1 (0.49) ALDH1A1PPARGPPARDPPARAKDM4E
SCHEMBL8481621 0.84 ALDH1A1 (0.71) ALDH1A1PPARGPPARDPPARAHTT
SCHEMBL15265592 0.82 ALDH1A1 (0.69) ALDH1A1PPARGPPARDPPARAHTT
SCHEMBL29624592 0.81 ALDH1A1 (0.45) ALDH1A1PPARGPPARDPPARACYP17A1
SCHEMBL28743513 0.81 ALDH1A1 (0.45) ALDH1A1PPARGPPARDPPARACYP17A1
SCHEMBL28743518 0.81 ALDH1A1 (0.45) ALDH1A1PPARGPPARDPPARACYP17A1
SCHEMBL16877074 0.81 HTT (0.45) ALDH1A1PPARGPPARDPPARACYP17A1
SCHEMBL12474333 0.81 CACNA1H (0.37) ALDH1A1PPARGPPARDPPARAHTT
SCHEMBL4659451 0.80 KDM4E (0.45) ALDH1A1PPARGPPARDPPARACYP17A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2376486-A1 NOVEL THIAZOLES DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS ADDEX Pharma S.A. (CH) 2011-10-19 EP disclosed
WO-2010079239-A1 NOVEL THIAZOLES DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS ADDEX PHARMA S.A. (CH) 2010-07-15 WO disclosed