Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.46 |
| ▸ | RORC | P51449 | 1/20 | 0.45 |
| ▸ | PDE4A | P27815 | 1/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.42 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 4/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.40 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.40 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.40 |
| ▸ | XPO1 | O14980 | 1/20 | 0.40 |
| ▸ | PTGES | O14684 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.39 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL426543 | 0.79 | TRPM8 (0.53) | L3MBTL1MAPTTRPM8RORCPDE4A | |
| SCHEMBL8236043 | 0.77 | ABL1 (0.55) | L3MBTL1MAPTTRPM8RORCABL1 | |
| SCHEMBL2482550 | 0.77 | TRPM8 (0.46) | L3MBTL1MAPTTRPM8RORCPDE4A | |
| SCHEMBL2485667 | 0.77 | TRPM8 (0.46) | L3MBTL1MAPTTRPM8PDE4APDE4B | |
| SCHEMBL2484620 | 0.74 | MAPT (0.46) | L3MBTL1MAPTTRPM8ALOX5DYRK3 | |
| SCHEMBL28368547 | 0.72 | MAPT (0.47) | L3MBTL1MAPTTRPM8RORCPDE4A | |
| SCHEMBL30541332 | 0.72 | MAPT (0.47) | L3MBTL1MAPTTRPM8RORCPDE4A | |
| SCHEMBL10872998 | 0.71 | KMT2A (0.40) | L3MBTL1MAPTALOX5KDM4EALDH1A1 | |
| SCHEMBL2482717 | 0.71 | CUL4A (0.45) | L3MBTL1MAPTGABRB2KDM4EALDH1A1 | |
| SCHEMBL28369187 | 0.71 | MAPT (0.46) | L3MBTL1MAPTRORCKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2376482-B1 | SUBSTITUTED (THIOPHENYL-CARBONYL)IMIDAZOLIDINONES, AND USE THEREOF | AICURIS GMBH & CO KG (DE) | 2013-03-06 | — | — | EP | disclosed |
| EP-2376482-A1 | SUBSTITUTED (THIOPHENYL-CARBONYL)IMIDAZOLIDINONES, AND USE THEREOF | AiCuris GmbH & Co. KG (DE) | 2011-10-19 | — | — | EP | disclosed |
| WO-2010075962-A1 | SUBSTITUTED (THIOPHENYL-CARBONYL)IMIDAZOLIDINONES, AND USE THEREOF | AICURIS GMBH & CO. KG (DE) | 2010-07-08 | — | — | WO | disclosed |