Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.41 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.41 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2482550 | 0.83 | TRPM8 (0.46) | TRPM8MAPTDYRK3DYRK1ADYRK2 | |
| SCHEMBL2481393 | 0.82 | XPO1 (0.39) | TRPM8MAPTNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL2477804 | 0.82 | NPC1 (0.40) | TRPM8MAPTL3MBTL1NPC1RAB9A | |
| SCHEMBL422050 | 0.81 | TRPM8 (0.53) | TRPM8MAPTL3MBTL1NPC1RAB9A | |
| SCHEMBL2506409 | 0.79 | PTGDR2 (0.44) | TRPM8MAPTDYRK3DYRK1ADYRK2 | |
| SCHEMBL8236842 | 0.77 | TRPM8 (0.49) | TRPM8MAPTDYRK3DYRK1ADYRK2 | |
| SCHEMBL2483240 | 0.77 | L3MBTL1 (0.46) | TRPM8MAPTDYRK3DYRK1ADYRK2 | |
| SCHEMBL2485581 | 0.74 | ALOX5 (0.47) | TRPM8MAPTL3MBTL1ALOX5KMT2A | |
| SCHEMBL2483769 | 0.73 | CUL4A (0.47) | MAPTL3MBTL1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL2486202 | 0.71 | ALOX5 (0.43) | TRPM8MAPTDYRK3DYRK1ADYRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2376482-B1 | SUBSTITUTED (THIOPHENYL-CARBONYL)IMIDAZOLIDINONES, AND USE THEREOF | AICURIS GMBH & CO KG (DE) | 2013-03-06 | — | — | EP | disclosed |
| EP-2376482-A1 | SUBSTITUTED (THIOPHENYL-CARBONYL)IMIDAZOLIDINONES, AND USE THEREOF | AiCuris GmbH & Co. KG (DE) | 2011-10-19 | — | — | EP | disclosed |
| WO-2010075962-A1 | SUBSTITUTED (THIOPHENYL-CARBONYL)IMIDAZOLIDINONES, AND USE THEREOF | AICURIS GMBH & CO. KG (DE) | 2010-07-08 | — | — | WO | disclosed |