Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B3 | P37058 | 6/20 | 0.68 |
| ▸ | SLC18A1 | P54219 | 1/20 | 0.67 |
| ▸ | SLC18A2 | Q05940 | 1/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.63 |
| ▸ | MAPT | P10636 | 1/20 | 0.63 |
| ▸ | POLB | P06746 | 2/20 | 0.61 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | KCNA2 | P16389 | 1/20 | 0.51 |
| ▸ | KCNA1 | Q09470 | 1/20 | 0.51 |
| ▸ | GLA | P06280 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | LCK | P06239 | 1/20 | 0.45 |
| ▸ | CASP1 | P29466 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24850946 | 0.86 | HSD17B3 (0.64) | HSD17B3SLC18A1SLC18A2KDM4EMAPT | |
| SCHEMBL14669803 | 0.82 | SLC18A1 (0.70) | HSD17B3SLC18A1SLC18A2KDM4EMAPT | |
| SCHEMBL5138108 | 0.81 | HSD17B3 (1.00) | HSD17B3KDM4EMAPTPOLBALDH1A1 | |
| SCHEMBL13480888 | 0.81 | HSD17B3 (0.73) | HSD17B3KDM4EMAPTALDH1A1KCNA2 | |
| SCHEMBL29360977 | 0.80 | SLC18A1 (1.00) | HSD17B3SLC18A1SLC18A2KDM4EMAPT | |
| SCHEMBL17299899 | 0.79 | CYP2D6 (0.72) | HSD17B3KDM4EMAPTPOLBCYP2D6 | |
| SCHEMBL655278 | 0.79 | HSD17B3 (0.71) | HSD17B3SLC18A1SLC18A2KDM4EMAPT | |
| Hydrochloric Acid SCHEMBL30603352 | 0.79 | SLC18A1 (0.97) | HSD17B3SLC18A1SLC18A2KDM4EMAPT | |
| SCHEMBL19398068 | 0.79 | LCK (0.66) | HSD17B3SLC18A1SLC18A2KDM4EALDH1A1 | |
| SCHEMBL14527910 | 0.79 | SLC18A1 (0.65) | HSD17B3SLC18A1SLC18A2KDM4EPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024146906-A1 | CASPASE-2 INHIBITOR COMPOUNDS | Kintsugi Therapeutics S.L. (ES) | 2024-07-11 | — | — | WO | disclosed |
| EP-4397674-A1 | CASPASE-2 INHIBITOR COMPOUNDS | Kintsugi Therapeutics S.L. (ES) | 2024-07-10 | — | — | EP | disclosed |
| WO-2023275357-A1 | CASPASE-2 INHIBITOR COMPOUNDS | Kintsugi Therapeutics S.L. (ES) | 2023-01-05 | — | — | WO | disclosed |
| EP-4112631-A1 | CASPASE-2 INHIBITOR COMPOUNDS | Kintsugi Therapeutics S.L. (ES) | 2023-01-04 | — | — | EP | disclosed |