Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 5/20 | 0.48 |
| ▸ | MAPT | P10636 | 5/20 | 0.48 |
| ▸ | RAB9A | P51151 | 5/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.48 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.48 |
| ▸ | RELA | Q04206 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | KDM4B | O94953 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31436986 | 0.79 | KDM4B (0.49) | ALDH1A1NPC1MAPTRAB9AHSD17B10 | |
| SCHEMBL10719025 | 0.77 | ALDH1A1 (0.61) | ALDH1A1NPC1MAPTRAB9AHSD17B10 | |
| SCHEMBL128834 | 0.77 | CYP19A1 (0.62) | ALDH1A1NPC1MAPTRAB9AHSD17B10 | |
| SCHEMBL29516285 | 0.77 | CYP19A1 (0.62) | ALDH1A1NPC1MAPTRAB9AHSD17B10 | |
| SCHEMBL2484207 | 0.77 | ALDH1A1 (0.49) | ALDH1A1NPC1MAPTRAB9AHSD17B10 | |
| SCHEMBL3405178 | 0.76 | KDM4A (0.47) | ALDH1A1MAPTRAB9AKDM4ENFKB1 | |
| Bromide SCHEMBL31361535 | 0.75 | CYP19A1 (0.61) | ALDH1A1NPC1MAPTRAB9AHSD17B10 | |
| SCHEMBL25392048 | 0.74 | HSD17B10 (0.61) | ALDH1A1NPC1MAPTRAB9AHSD17B10 | |
| SCHEMBL30426286 | 0.74 | HSD17B10 (0.61) | ALDH1A1NPC1MAPTRAB9AHSD17B10 | |
| SCHEMBL31436956 | 0.73 | ALDH1A1 (0.48) | ALDH1A1NPC1MAPTRAB9AHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2376486-A1 | NOVEL THIAZOLES DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | ADDEX Pharma S.A. (CH) | 2011-10-19 | — | — | EP | claimed |
| CN-116143773-B | 2-amino-4-thiazolylpyrimidine compound and preparation method and application thereof | 中国药科大学 | 2023-07-21 | — | — | CN | disclosed |
| CN-116143773-A | 2-amino-4-thiazolylpyrimidine compound and preparation method and application thereof | 中国药科大学 | 2023-05-23 | — | — | CN | disclosed |
| EP-2376486-A1 | NOVEL THIAZOLES DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | ADDEX Pharma S.A. (CH) | 2011-10-19 | — | — | EP | disclosed |