Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4A | O75164 | 1/20 | 0.47 |
| ▸ | KDM4B | O94953 | 1/20 | 0.47 |
| ▸ | KDM5C | P41229 | 1/20 | 0.47 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 2/20 | 0.44 |
| ▸ | GRM5 | P41594 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 5/20 | 0.43 |
| ▸ | ECE1 | P42892 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.42 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.41 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24359598 | 0.78 | GAA (0.52) | KDM4AKDM4BKDM5CKDM5BRECQL | |
| SCHEMBL21366338 | 0.78 | HRH1 (0.42) | CYP19A1GRM1 | |
| SCHEMBL10272523 | 0.78 | CYP19A1 (0.61) | KDM4AKDM4BKDM5CKDM5BGRM5 | |
| SCHEMBL1828888 | 0.77 | KDM4B (0.48) | KDM4AKDM4BKDM5CKDM5BRECQL | |
| SCHEMBL2483296 | 0.76 | ALDH1A1 (0.52) | KDM4AKDM4BKDM5CKDM5BKDM4E | |
| SCHEMBL16675864 | 0.74 | KDM4A (0.48) | KDM4AKDM4BKDM5CKDM5BRECQL | |
| SCHEMBL21448899 | 0.74 | TLR7 (0.44) | HTTCYP19A1GRM1TLR7 | |
| SCHEMBL4636838 | 0.74 | KDM4E (0.59) | KDM4AKDM4BKDM5CKDM5BGAA | |
| SCHEMBL13078713 | 0.72 | KDM4E (0.42) | KDM4AKDM4BKDM5CKDM5BRECQL | |
| SCHEMBL19626505 | 0.72 | GRM5 (0.52) | KDM4AKDM4BKDM5CKDM5BRECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3564239-A1 | ARYL HYDROCARBON RECEPTOR MODULATOR | Shenzhen Immunova Pharmaceutical Co., Ltd. (CN) | 2019-11-06 | — | — | EP | disclosed |
| EP-2257539-A1 | SUBSTITUTED 4-HYDROXYPYRIMIDINE-5-CARBOXAMIDES | Merck Sharp & Dohme Corp. (US) | 2010-12-08 | — | — | EP | disclosed |
| WO-2009117269-A1 | SUBSTITUTED 4-HYDROXYPYRIMIDINE-5-CARBOXAMIDES | MERCK & CO., INC. (US) | 2009-09-24 | — | — | WO | disclosed |