Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | CRBN | Q96SW2 | 4/20 | 0.37 |
| ▸ | DDB1 | Q16531 | 3/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.36 |
| ▸ | PIN4 | Q9Y237 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 4/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.35 |
| ▸ | LPAR3 | Q9UBY5 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5478671 | 0.89 | ALDH1A1 (0.43) | ALDH1A1CRBNDDB1TSHRMEN1 | |
| SCHEMBL25696450 | 0.85 | ALDH1A1 (0.37) | ALDH1A1MAPK1CRBNDDB1TSHR | |
| SCHEMBL24294557 | 0.81 | CRBN (0.45) | CRBNDDB1TSHR | |
| Hydrochloric Acid SCHEMBL7742015 | 0.77 | CYP1A2 (0.43) | ALDH1A1CRBNDDB1TSHRMEN1 | |
| SCHEMBL5475099 | 0.76 | CYP1A2 (0.39) | ALDH1A1CRBNDDB1TSHRMEN1 | |
| SCHEMBL2910295 | 0.76 | L3MBTL1 (0.40) | ALDH1A1CRBNDDB1TSHRKMT2A | |
| SCHEMBL3592001 | 0.76 | ALDH1A1 (0.41) | ALDH1A1CRBNDDB1TSHRMEN1 | |
| SCHEMBL2918755 | 0.76 | ALDH1A1 (0.41) | ALDH1A1CRBNDDB1TSHRMEN1 | |
| SCHEMBL13297907 | 0.75 | DDB1 (0.43) | ALDH1A1CRBNDDB1TSHRMEN1 | |
| SCHEMBL13167679 | 0.75 | L3MBTL1 (0.41) | ALDH1A1CRBNDDB1TSHRKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023274390-A1 | BRUTON'S TYROSINE KINASE AND MUTANT DEGRADER, COMPOSITION AND APPLICATION THEREOF | 杭州和正医药有限公司 | 2023-01-05 | — | — | WO | disclosed |