⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27179088 | 0.80 | MAPK1 (0.36) | — | |
| SCHEMBL11889880 | 0.76 | ALDH1A1 (0.34) | — | |
| SCHEMBL8008896 | 0.76 | LMNA (0.31) | — | |
| SCHEMBL27475390 | 0.75 | — | — | |
| SCHEMBL603446 | 0.74 | — | — | |
| SCHEMBL600923 | 0.74 | DPP4 (0.34) | — | |
| SCHEMBL19889819 | 0.74 | KAT2B (0.34) | — | |
| SCHEMBL9998858 | 0.72 | LMNA (0.35) | — | |
| SCHEMBL19293551 | 0.72 | CHRM3 (0.33) | — | |
| SCHEMBL2307358 | 0.72 | POLB (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023278402-A1 | SMARCA DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2023-01-05 | — | — | WO | disclosed |