Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.42 |
| ▸ | GABRA1 | P14867 | 4/20 | 0.41 |
| ▸ | GABRA5 | P31644 | 4/20 | 0.41 |
| ▸ | GABRG2 | P18507 | 3/20 | 0.41 |
| ▸ | GABRB3 | P28472 | 3/20 | 0.41 |
| ▸ | GABRA3 | P34903 | 3/20 | 0.41 |
| ▸ | GABRA2 | P47869 | 3/20 | 0.41 |
| ▸ | GABRA6 | Q16445 | 3/20 | 0.41 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.41 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.40 |
| ▸ | KDM4A | O75164 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | GFER | P55789 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26932101 | 0.88 | GABRA1 (0.38) | TRPV1GABRA1GABRA5GABRG2GABRB3 | |
| SCHEMBL24838771 | 0.87 | GABRA1 (0.42) | TRPV1GABRA1GABRA5GABRG2GABRB3 | |
| SCHEMBL30178965 | 0.87 | GABRA1 (0.42) | GABRA1GABRA5GABRG2GABRB3GABRA3 | |
| SCHEMBL24837858 | 0.87 | GABRA1 (0.42) | GABRA1GABRA5GABRG2GABRB3GABRA3 | |
| SCHEMBL24838783 | 0.87 | TRPV1 (0.44) | TRPV1ABCB1PTPN11KDM4AL3MBTL1 | |
| SCHEMBL30683092 | 0.86 | GABRA1 (0.40) | TRPV1GABRA1GABRA5GABRG2GABRB3 | |
| SCHEMBL15729791 | 0.86 | GABRA1 (0.41) | TRPV1GABRA1GABRA5GABRG2GABRB3 | |
| SCHEMBL26931830 | 0.86 | GABRA1 (0.41) | GABRA1GABRA5GABRG2GABRB3GABRA3 | |
| SCHEMBL24838313 | 0.86 | IDO1 (0.43) | TRPV1GABRA1GABRA5GABRG2GABRB3 | |
| SCHEMBL23775495 | 0.84 | ABCB1 (0.43) | TRPV1ABCB1PTPN11KDM4AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023239645-A1 | SMARCA DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2023-12-14 | — | — | WO | disclosed |
| WO-2023239645-A1 | SMARCA DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2023-12-14 | — | — | WO | disclosed |
| WO-2023278402-A1 | SMARCA DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2023-01-05 | — | — | WO | disclosed |
| WO-2023278402-A1 | SMARCA DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2023-01-05 | — | — | WO | disclosed |