Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 1/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.44 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.44 |
| ▸ | JAK2 | O60674 | 7/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 4/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL519748 | 0.85 | JAK2 (0.56) | PIK3CDPIK3CAPIK3CGJAK2ALDH1A1 | |
| SCHEMBL2482773 | 0.85 | PIK3CD (0.47) | PIK3CDPIK3CAPIK3CGJAK2ALDH1A1 | |
| SCHEMBL520240 | 0.82 | KCNH2 (0.48) | PIK3CAJAK2PTK2 | |
| SCHEMBL522076 | 0.77 | JAK2 (0.41) | JAK2PTK2 | |
| SCHEMBL519850 | 0.76 | JAK2 (0.38) | JAK2PTK2 | |
| SCHEMBL519625 | 0.75 | JAK2 (0.48) | PIK3CDPIK3CAPIK3CGJAK2ALDH1A1 | |
| SCHEMBL3470162 | 0.74 | CDK9 (0.42) | JAK2PTK2 | |
| SCHEMBL521702 | 0.74 | FYN (0.35) | JAK2ALDH1A1PTK2 | |
| SCHEMBL519160 | 0.73 | DYRK3 (0.43) | JAK2ALDH1A1PTK2MAPTLMNA | |
| SCHEMBL519903 | 0.73 | JAK2 (0.41) | JAK2PTK2BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2376491-A1 | PYRROLOTRIAZINES AS ALK AND JAK2 INHIBITORS | Cephalon, Inc. (US) | 2011-10-19 | — | — | EP | disclosed |
| WO-2010071885-A1 | PYRROLOTRIAZINES AS ALK AND JAK2 INHIBITORS | CEPHALON, INC. (US) | 2010-06-24 | — | — | WO | disclosed |