Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 13/20 | 0.41 |
| ▸ | PTK2 | Q05397 | 4/20 | 0.41 |
| ▸ | BRD4 | O60885 | 4/20 | 0.37 |
| ▸ | INSR | P06213 | 1/20 | 0.36 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.36 |
| ▸ | FYN | P06241 | 6/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL519625 | 0.89 | JAK2 (0.48) | JAK2PTK2BRD4FYN | |
| SCHEMBL521326 | 0.82 | KDM4E (0.45) | FYN | |
| SCHEMBL519850 | 0.80 | JAK2 (0.38) | JAK2PTK2INSRALKFYN | |
| SCHEMBL519748 | 0.80 | JAK2 (0.56) | JAK2PTK2 | |
| SCHEMBL520240 | 0.79 | KCNH2 (0.48) | JAK2PTK2FYN | |
| SCHEMBL3470162 | 0.77 | CDK9 (0.42) | JAK2PTK2INSRALKFYN | |
| SCHEMBL519160 | 0.76 | DYRK3 (0.43) | JAK2PTK2INSRALKFYN | |
| SCHEMBL521133 | 0.76 | INSR (0.40) | JAK2PTK2INSRALKFYN | |
| SCHEMBL520970 | 0.76 | FYN (0.40) | FYN | |
| SCHEMBL521544 | 0.76 | JAK2 (0.47) | JAK2PTK2BRD4INSRALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120028919-A1 | PYRROLOTRIAZINES AS ALK AND JAK2 INHIBITORS | CEPHALON, INC. (US) | 2012-02-02 | — | — | US | disclosed |
| EP-2376491-A1 | PYRROLOTRIAZINES AS ALK AND JAK2 INHIBITORS | Cephalon, Inc. (US) | 2011-10-19 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120028919-A1 | PYRROLOTRIAZINES AS ALK AND JAK2 INHIBITORS | JAK2, ALK, ABL1 | JAK2 1/4885PTK2 592/4885BRD4 23/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.