SCHEMBL24838245

SCHEMBL24838245

C#Cc1ccc(CN)c(Cl)c1

nearest known ligand 0.48

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
PNMT P11086 2/20 0.48
DPP4 P27487 2/20 0.38
LOXL2 Q9Y4K0 1/20 0.37
PYCR1 P32322 2/20 0.34
IDO1 P14902 3/20 0.33
HTR2C P28335 1/20 0.33
HTR2B P41595 1/20 0.33
TAAR1 Q96RJ0 1/20 0.32
EGFR P00533 1/20 0.32
KDR P35968 1/20 0.32
CA12 O43570 1/20 0.32
CA1 P00915 1/20 0.32
CA2 P00918 1/20 0.32
CA9 Q16790 1/20 0.32
CA14 Q9ULX7 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11237503 0.80 PYCR1 (0.38) PYCR1IDO1CA12CA1CA2
SCHEMBL2678910 0.80 LOXL2 (0.47) PNMTLOXL2
Hydrochloric Acid SCHEMBL6490072 0.78 LOXL2 (0.45) PNMTLOXL2IDO1
SCHEMBL11234649 0.77 PYCR1 (0.39) PYCR1IDO1TAAR1EGFR
SCHEMBL24837945 0.76 LOXL2 (0.38) LOXL2PYCR1IDO1HTR2CHTR2B
SCHEMBL22954538 0.76 LOXL2 (0.37) PNMTLOXL2PYCR1HTR2CHTR2B
SCHEMBL24837812 0.76 LOXL2 (0.37) PNMTLOXL2HTR2CHTR2BCA12
SCHEMBL30200755 0.76 LOXL2 (0.37) PNMTLOXL2HTR2CHTR2BCA12
SCHEMBL26016357 0.76 PYCR1 (0.35) PYCR1EGFRKDR
SCHEMBL11226592 0.76 PYCR1 (0.35) PNMTPYCR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119998278-A Compounds and uses thereof 福宏治疗公司 2025-05-13 CN disclosed
EP-4522278-A1 BENZOYPARAZINE PYRAZINES ANE THEIR USES Foghorn Therapeutics Inc. (US) 2025-03-19 EP disclosed
WO-2023239645-A1 SMARCA DEGRADERS AND USES THEREOF KYMERA THERAPEUTICS, INC. (US) 2023-12-14 WO disclosed
WO-2023239645-A1 SMARCA DEGRADERS AND USES THEREOF KYMERA THERAPEUTICS, INC. (US) 2023-12-14 WO disclosed
WO-2023220129-A1 BENZOYPARAZINE PYRAZINES ANE THEIR USES FOGHORN THERAPEUTICS INC. (US) 2023-11-16 WO disclosed
WO-2023220129-A1 BENZOYPARAZINE PYRAZINES ANE THEIR USES FOGHORN THERAPEUTICS INC. (US) 2023-11-16 WO disclosed
US-20230173078-A1 SMARCA DEGRADERS AND USES THEREOF KYMERA THERAPEUTICS, INC. 2023-06-08 US disclosed
US-20230173078-A1 SMARCA DEGRADERS AND USES THEREOF KYMERA THERAPEUTICS, INC. 2023-06-08 US disclosed
WO-2023278402-A1 SMARCA DEGRADERS AND USES THEREOF KYMERA THERAPEUTICS, INC. (US) 2023-01-05 WO disclosed
WO-2023278402-A1 SMARCA DEGRADERS AND USES THEREOF KYMERA THERAPEUTICS, INC. (US) 2023-01-05 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230173078-A1 SMARCA DEGRADERS AND USES THEREOF SMARCA1, SMARCA2, SMARCC2 PNMT 1247/4885DPP4 4421/4885LOXL2 2878/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.