Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 | P32246 | 2/20 | 0.57 |
| ▸ | CCR5 | P51681 | 2/20 | 0.57 |
| ▸ | CCR8 | P51685 | 2/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | PSMD14 | O00487 | 2/20 | 0.42 |
| ▸ | COPS5 | Q92905 | 2/20 | 0.42 |
| ▸ | HTR1A | P08908 | 2/20 | 0.36 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.36 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.36 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.36 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.36 |
| ▸ | TRPA1 | O75762 | 3/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24010300 | 0.81 | KDM4E (0.40) | HTR1AADRA1DADRA1AADRA1BTRPA1 | |
| SCHEMBL8032037 | 0.80 | CCR1 (0.69) | CCR1CCR5CCR8L3MBTL1PSMD14 | |
| SCHEMBL20561953 | 0.79 | CCR1 (0.57) | CCR1CCR5CCR8L3MBTL1PSMD14 | |
| SCHEMBL26400628 | 0.79 | KRAS (0.35) | CCR1CCR5CCR8HTR1AADRA1D | |
| SCHEMBL22280199 | 0.78 | CCR1 (0.65) | CCR1CCR5CCR8L3MBTL1PSMD14 | |
| SCHEMBL1337689 | 0.75 | HTR1A (0.61) | CCR1CCR5CCR8L3MBTL1PSMD14 | |
| SCHEMBL182930 | 0.74 | CCR1 (1.00) | CCR1CCR5CCR8L3MBTL1PSMD14 | |
| SCHEMBL29563986 | 0.74 | CCR1 (1.00) | CCR1CCR5CCR8L3MBTL1PSMD14 | |
| SCHEMBL20782661 | 0.73 | PDGFRA (0.44) | PDGFRBPDGFRATRPA1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL20561936 | 0.73 | CCR1 (0.49) | CCR1CCR5CCR8L3MBTL1PSMD14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11780849-B2 | Imino sulfanone inhibitors of ENPP1 | VOLASTRA THERAPEUTICS, INC. (US) | 2023-10-10 | — | — | US | disclosed |
| US-20230002406-A1 | IMINO SULFANONE INHIBITORS OF ENPP1 | VOLASTRA THERAPEUTICS, INC. (US) | 2023-01-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11780849-B2 | Imino sulfanone inhibitors of ENPP1 | ENPP1, ENPP3, SMPD1 | CCR1 4554/4885CCR5 4263/4885CCR8 4424/4885 |
| US-20230002406-A1 | IMINO SULFANONE INHIBITORS OF ENPP1 | ENPP1, ENPP3, SMPD1 | CCR1 4554/4885CCR5 4263/4885CCR8 4424/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.