Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | INSR | P06213 | 2/20 | 0.45 |
| ▸ | NPM1 | P06748 | 2/20 | 0.45 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | RAD52 | P43351 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.41 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 2/20 | 0.41 |
| ▸ | IGF1R | P08069 | 2/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL520419 | 1.00 | INSR (0.45) | INSRNPM1ALKMAPTGAA | |
| SCHEMBL519957 | 0.95 | INSR (0.48) | INSRNPM1ALKMAPTGAA | |
| SCHEMBL519652 | 0.95 | INSR (0.48) | INSRNPM1ALKMAPTGAA | |
| SCHEMBL519653 | 0.95 | INSR (0.48) | INSRNPM1ALKMAPTGAA | |
| SCHEMBL520411 | 0.90 | ADRA2A (0.49) | MAPTMEN1KMT2AATMALDH1A1 | |
| SCHEMBL2207628 | 0.86 | GAA (0.47) | INSRNPM1ALKMAPTGAA | |
| SCHEMBL520934 | 0.84 | ADRA2A (0.53) | MAPTMEN1KMT2AATMTP53 | |
| SCHEMBL14180538 | 0.84 | TLR9 (0.48) | ALKGAARAD52ALDH1A1 | |
| SCHEMBL520282 | 0.84 | ADRA2A (0.53) | MAPTMEN1KMT2AATMTP53 | |
| SCHEMBL520281 | 0.84 | ADRA2A (0.53) | MAPTMEN1KMT2AATMTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2376491-A1 | PYRROLOTRIAZINES AS ALK AND JAK2 INHIBITORS | Cephalon, Inc. (US) | 2011-10-19 | — | — | EP | disclosed |
| WO-2010071885-A1 | PYRROLOTRIAZINES AS ALK AND JAK2 INHIBITORS | CEPHALON, INC. (US) | 2010-06-24 | — | — | WO | disclosed |