Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.41 |
| ▸ | TGM2 | P21980 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C18 | P33260 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27893458 | 0.85 | HRH3 (0.47) | HRH3MAPK1KMT2ANPC1RAB9A | |
| SCHEMBL64453 | 0.85 | HRH3 (0.54) | HRH3MAPK1KMT2ANPC1RAB9A | |
| SCHEMBL14875984 | 0.83 | HRH3 (0.57) | HRH3MAPK1KMT2ANPC1RAB9A | |
| SCHEMBL25246829 | 0.82 | HRH3 (0.57) | HRH3MAPK1KMT2ANPC1RAB9A | |
| SCHEMBL23961033 | 0.82 | HRH3 (0.57) | HRH3MAPK1KMT2AMAPTMEN1 | |
| SCHEMBL31073082 | 0.82 | TRPC6 (0.54) | HRH3MAPK1KMT2ANPC1RAB9A | |
| SCHEMBL30263227 | 0.82 | HRH3 (0.57) | HRH3MAPK1KMT2AMAPTMEN1 | |
| SCHEMBL29913781 | 0.82 | SMN1; SMN2 (0.60) | HRH3KMT2AGPR119MAPTMEN1 | |
| SCHEMBL14802410 | 0.82 | SMN1; SMN2 (0.60) | HRH3KMT2AGPR119MAPTMEN1 | |
| SCHEMBL24107649 | 0.81 | HRH3 (0.51) | HRH3MAPK1KMT2ANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2588453-A1 | COMPOSITIONS AND METHODS FOR MODULATING THE WNT SIGNALING PATHWAY | IRM LLC (BM) | 2013-05-08 | — | — | EP | disclosed |
| WO-2012003189-A1 | COMPOSITIONS AND METHODS FOR MODULATING THE WNT SIGNALING PATHWAY | IRM LLC (BM) | 2012-01-05 | — | — | WO | disclosed |