Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | CASP3 | P42574 | 2/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CES2 | O00748 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | EDNRB | P24530 | 1/20 | 0.36 |
| ▸ | EDNRA | P25101 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | MITF | O75030 | 1/20 | 0.35 |
| ▸ | NSD2 | O96028 | 1/20 | 0.35 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.35 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.35 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | PTPRC | P08575 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8736635 | 0.89 | EDNRB (0.42) | HTR2ACASP3CA1CA2CES2 | |
| SCHEMBL252162 | 0.81 | HTR2A (0.52) | HTR2ACA1CA2CES2ALDH1A1 | |
| SCHEMBL8546525 | 0.77 | KDM4E (0.37) | CASP3CES2KMT2AMEN1EDNRB | |
| SCHEMBL9536703 | 0.72 | CES2 (0.32) | HTR2ACES2 | |
| SCHEMBL4552155 | 0.72 | IDO1 (0.45) | HTR2APOLBALDH1A1LMNAHTT | |
| SCHEMBL9547888 | 0.72 | HTR2A (0.42) | HTR2ACA1CA2KMT2AMEN1 | |
| SCHEMBL11764926 | 0.71 | EDNRB (0.47) | HTR2AEDNRBEDNRAHTTCYP1A2 | |
| SCHEMBL4551141 | 0.70 | HTR2A (0.39) | HTR2ACASP3CA1CA2CES2 | |
| SCHEMBL16859501 | 0.70 | HSD17B10 (0.55) | HTR2AALDH1A1CYP1A2KDM4EHPGD | |
| SCHEMBL5140755 | 0.69 | CA1 (0.37) | HTR2ACA1CA2CES2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2364982-A1 | Spiro-piperidine compounds as chemokine receptor antagonists and medicinal use thereof | ONO Pharmaceutical Co., Ltd. (JP) | 2011-09-14 | — | — | EP | disclosed |
| EP-1621540-A1 | NITROGEN-CONTAINING HETEROCYCLIC COMPOUNDS AND USE THEREOF | ONO PHARMACEUTICAL CO., LTD. (JP) | 2006-02-01 | — | — | EP | disclosed |
| EP-1619193-A1 | SPIROPIPERIDINE COMPOUND AND MEDICINAL USE THEREOF | ONO PHARMACEUTICAL CO., LTD. (JP) | 2006-01-25 | — | — | EP | disclosed |