Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 1/20 | 0.42 |
| ▸ | MPO | P05164 | 3/20 | 0.40 |
| ▸ | HTR2A | P28223 | 2/20 | 0.40 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.40 |
| ▸ | TLR8 | Q9NR97 | 5/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | BACE1 | P56817 | 1/20 | 0.36 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.33 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.33 |
| ▸ | DHFR | P00374 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | TERT | O14746 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL248441 | 0.77 | HTR2C (0.37) | HTR2ABACE1HRH4DHFR | |
| SCHEMBL19331559 | 0.73 | IDO1 (0.39) | IDO1MPOHTR2ATRPM8TLR8 | |
| SCHEMBL19331494 | 0.72 | DHODH (0.41) | IDO1KMT2AATMTAAR1HTT | |
| SCHEMBL19331478 | 0.71 | TAAR1 (0.47) | IDO1MPOHTR2ATRPM8KMT2A | |
| SCHEMBL16585417 | 0.70 | FERMT2 (0.37) | IDO1MPOHTR2ATRPM8HTR1A | |
| SCHEMBL4433283 | 0.70 | KDM4E (0.43) | IDO1KMT2ABACE1TAAR1 | |
| SCHEMBL14352666 | 0.69 | IDO1 (0.46) | IDO1MPOHTR2ATRPM8HTR1A | |
| SCHEMBL28609423 | 0.69 | TLR8 (0.54) | TLR8KMT2AATM | |
| SCHEMBL15320225 | 0.69 | PIK3CD (0.43) | NPC1HTTRAB9A | |
| Ammonia Solution, Strong SCHEMBL9131397 | 0.68 | TLR8 (0.53) | TLR8KMT2AATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2588469-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE AS INHIBITORS OF PI3K ACTIVITY | Amgen Inc. (US) | 2013-05-08 | — | — | EP | disclosed |
| WO-2012003271-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE AS INHIBITORS OF PI3K ACTIVITY | AMGEN INC. (US) | 2012-01-05 | — | — | WO | disclosed |