Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 10/20 | 0.53 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | LCK | P06239 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.41 |
| ▸ | PDE4A | P27815 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28609423 | 0.98 | TLR8 (0.54) | TLR8ATMALDH1A1HPGDGLA | |
| SCHEMBL28214718 | 0.90 | TLR8 (0.62) | TLR8ATMALDH1A1HPGDGLA | |
| Formamide SCHEMBL28779301 | 0.89 | TLR8 (0.50) | TLR8ATMALDH1A1KMT2ALCK | |
| SCHEMBL14782918 | 0.86 | TLR8 (0.50) | TLR8ATMALDH1A1HPGDGLA | |
| SCHEMBL28162401 | 0.84 | TLR8 (0.69) | TLR8ATMALDH1A1HPGDGLA | |
| SCHEMBL168398 | 0.83 | TLR8 (0.69) | TLR8ALDH1A1HPGDGLAMAPT | |
| SCHEMBL28793625 | 0.81 | TLR8 (0.68) | TLR8ALDH1A1HPGDGLAMAPT | |
| SCHEMBL27870558 | 0.81 | TLR8 (0.68) | TLR8ALDH1A1HPGDGLAMAPT | |
| SCHEMBL19260213 | 0.80 | TDP1 (0.52) | TLR8ATMALDH1A1HPGDGLA | |
| SCHEMBL28146814 | 0.79 | TLR8 (0.62) | TLR8ATMALDH1A1HPGDGLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107501297-B | Phenothiazine-pyridine compounds and uses thereof | 香港中文大学 | 2020-12-01 | — | — | CN | disclosed |
| US-5436240-A | Schizophrenia, Parkinson's disease, depression or hypotensive agents using tricyclic amines | THE UPJOHN COMPANY (US) | 1995-07-25 | — | — | US | disclosed |