Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | TAAR1 | Q96RJ0 | 4/20 | 0.41 |
| ▸ | DPP4 | P27487 | 4/20 | 0.40 |
| ▸ | MAOB | P27338 | 2/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.37 |
| ▸ | PDE2A | O00408 | 1/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.35 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.35 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4184832 | 0.91 | DPP4 (0.47) | KDM4EALDH1A1GLADPP4ACHE | |
| SCHEMBL4435974 | 0.88 | KDM4E (0.45) | KDM4EALDH1A1GLADPP4ACHE | |
| SCHEMBL19331494 | 0.82 | DHODH (0.41) | KDM4EALDH1A1TAAR1DPP4IDO1 | |
| SCHEMBL4443375 | 0.82 | SMN1; SMN2 (0.42) | KDM4EALDH1A1ACHEPDE10AMAPK11 | |
| SCHEMBL15320830 | 0.81 | PIK3CD (0.48) | HSD11B1PDE2A | |
| SCHEMBL4191733 | 0.80 | DPP4 (0.47) | KDM4EALDH1A1GLADPP4ACHE | |
| SCHEMBL19331478 | 0.78 | TAAR1 (0.47) | KDM4ETAAR1DPP4IDO1KMT2A | |
| SCHEMBL4178581 | 0.78 | DPP4 (0.48) | KDM4EALDH1A1GLATAAR1DPP4 | |
| SCHEMBL15320225 | 0.78 | PIK3CD (0.43) | KDM4EALDH1A1GAA | |
| SCHEMBL16597047 | 0.78 | MBNL1 (0.54) | KDM4EALDH1A1GLAACHEBACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2137186-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | Amgen Inc. (US) | 2009-12-30 | — | — | EP | disclosed |
| WO-2008118468-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USES | AMGEN INC. (US) | 2008-10-02 | — | — | WO | disclosed |