Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3462566 | 0.87 | ATR (0.66) | ATRCYP3A4 | |
| SCHEMBL3462644 | 0.85 | ATR (0.71) | ATRCYP3A4 | |
| SCHEMBL20433206 | 0.84 | ATR (0.67) | ATRCYP3A4 | |
| SCHEMBL2486385 | 0.84 | ATR (0.70) | ATRCYP3A4 | |
| SCHEMBL2484993 | 0.83 | ATR (0.73) | ATRCYP3A4 | |
| SCHEMBL23389767 | 0.82 | ATR (0.57) | ATR | |
| SCHEMBL19672699 | 0.81 | ATR (0.62) | ATRCYP3A4 | |
| SCHEMBL23389810 | 0.81 | ATR (0.67) | ATR | |
| SCHEMBL2482344 | 0.81 | ATR (1.00) | ATRCYP3A4 | |
| SCHEMBL2483634 | 0.80 | ATR (1.00) | ATRCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 61 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3684184-B1 | HERBICIDALLY ACTIVE PYRIDYL-/PYRIMIDYL-PYRAZINE DERIVATIVES | SYNGENTA PARTICIPATIONS AG (CH) | 2023-06-21 | — | — | EP | claimed |
| US-20220144801-A1 | HERBICIDALLY ACTIVE PYRIDYL-/PYRIMIDYL-PYRAZINE DERIVATIVES | SYNGENTA PARTICIPATIONS AG (CH) | 2022-05-12 | — | — | US | claimed |
| US-11229205-B2 | Herbicidally active pyridyl-/pyrimidyl-pyrazine derivatives | SYNGENTA PARTICIPATIONS AG (CH) | 2022-01-25 | — | — | US | claimed |
| US-20200267984-A1 | Herbicidally Active Pyridyl-/Pyrimidyl-Pyrazine Derivatives | SYNGENTA PARTICIPATIONS AG (CH) | 2020-08-27 | — | — | US | claimed |
| EP-3684184-A1 | HERBICIDALLY ACTIVE PYRIDYL-/PYRIMIDYL-PYRAZINE DERIVATIVES | Syngenta Participations AG (CH) | 2020-07-29 | — | — | EP | claimed |
| CN-111372456-A | Herbicidally active pyridyl-/pyrimidinyl-pyrazine derivatives | 先正达参股股份有限公司 | 2020-07-03 | — | — | CN | claimed |
| WO-2019057723-A1 | HERBICIDALLY ACTIVE PYRIDYL-/PYRIMIDYL-PYRAZINE DERIVATIVES | SYNGENTA PARTICIPATIONS AG (CH) | 2019-03-28 | — | — | WO | claimed |
| EP-3684184-B1 | HERBICIDALLY ACTIVE PYRIDYL-/PYRIMIDYL-PYRAZINE DERIVATIVES | SYNGENTA PARTICIPATIONS AG (CH) | 2023-06-21 | — | — | EP | disclosed |
| US-20230030414-A1 | COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE | VERTEX PHARMACEUTICALS INCORPORATED | 2023-02-02 | — | — | US | disclosed |
| US-20230030414-A1 | COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE | VERTEX PHARMACEUTICALS INCORPORATED | 2023-02-02 | — | — | US | disclosed |
| CN-111372456-B | Herbicidally active pyridyl-/pyrimidinyl-pyrazine derivatives | 先正达参股股份有限公司 | 2022-10-18 | — | — | CN | disclosed |
| EP-4059932-A1 | COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE | Vertex Pharmaceuticals Incorporated (US) | 2022-09-21 | — | — | EP | disclosed |
| EP-4059932-A1 | COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE | Vertex Pharmaceuticals Incorporated (US) | 2022-09-21 | — | — | EP | disclosed |
| US-8841308-B2 | Pyrazin-2-amines useful as inhibitors of ATR kinase | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2014-09-23 | — | — | US | disclosed |
| EP-2376485-A1 | PYRAZINE DERIVATIVES USEFUL AS INHIBITORS OF ATR KINASE | Vertex Pharmaceuticals Incorporated (US) | 2011-10-19 | — | — | EP | disclosed |
| US-20100222318-A1 | COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-09-02 | — | — | US | disclosed |
| US-20100222318-A1 | COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-09-02 | — | — | US | disclosed |
| US-20100222318-A1 | COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-09-02 | — | — | US | disclosed |
| WO-2010071837-A1 | PYRAZINE DERIVATIVES USEFUL AS INHIBITORS OF ATR KINASE | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-06-24 | — | — | WO | disclosed |
| WO-2010071837-A1 | PYRAZINE DERIVATIVES USEFUL AS INHIBITORS OF ATR KINASE | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-06-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100222318-A1 | COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE | ATR, CHEK1, MAP3K5 | ATR 1/4885CYP3A4 4141/4885 |
| US-20230030414-A1 | COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE | ATR, CHEK1, MAP3K5 | ATR 1/4885CYP3A4 4141/4885 |
| US-20200267984-A1 | Herbicidally Active Pyridyl-/Pyrimidyl-Pyrazine Derivatives | DDT, HPD, PLPBP | ATR 2054/4885CYP3A4 636/4885 |
| US-20220144801-A1 | HERBICIDALLY ACTIVE PYRIDYL-/PYRIMIDYL-PYRAZINE DERIVATIVES | DDT, HPD, PLPBP | ATR 2054/4885CYP3A4 636/4885 |
| US-11229205-B2 | Herbicidally active pyridyl-/pyrimidyl-pyrazine derivatives | DDT, HPD, PLPBP | ATR 2054/4885CYP3A4 636/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.