Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Asparagine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS2 | P35228 | 2/20 | 0.41 |
| ▸ | NOS3 | P29474 | 1/20 | 0.41 |
| ▸ | NOS1 | P29475 | 1/20 | 0.41 |
| ▸ | GRIK1 | P39086 | 6/20 | 0.39 |
| ▸ | GRIK2 | Q13002 | 2/20 | 0.39 |
| ▸ | BLM | P54132 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | GLI1 | P08151 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.35 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.35 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.35 |
| ▸ | GRIK3 | Q13003 | 1/20 | 0.35 |
| ▸ | GRIK5 | Q16478 | 1/20 | 0.35 |
| ▸ | DPP4 | P27487 | 1/20 | 0.35 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.35 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.34 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Asparagine SCHEMBL27708267 | 1.00 | NOS2 (0.41) | NOS2NOS3NOS1GRIK1GRIK2 | |
| Asparagine SCHEMBL28801809 | 1.00 | NOS2 (0.41) | NOS2NOS3NOS1GRIK1GRIK2 | |
| Asparagine SCHEMBL28252029 | 1.00 | NOS2 (0.41) | NOS2NOS3NOS1GRIK1GRIK2 | |
| Asparagine SCHEMBL2484607 | 1.00 | NOS2 (0.41) | NOS2NOS3NOS1GRIK1GRIK2 | |
| Asparagine SCHEMBL2537696 | 1.00 | NOS2 (0.41) | NOS2NOS3NOS1GRIK1GRIK2 | |
| Asparagine SCHEMBL2537700 | 1.00 | NOS2 (0.41) | NOS2NOS3NOS1GRIK1GRIK2 | |
| Asparagine SCHEMBL537634 | 0.94 | NOS2 (0.37) | NOS2NOS3NOS1GRIK1GRIK2 | |
| Asparagine SCHEMBL2440846 | 0.94 | NOS2 (0.37) | NOS2NOS3NOS1GRIK1GRIK2 | |
| Asparagine SCHEMBL4607285 | 0.94 | NOS2 (0.37) | NOS2NOS3NOS1GRIK1GRIK2 | |
| Asparagine SCHEMBL4354914 | 0.94 | NOS2 (0.37) | NOS2NOS3NOS1GRIK1GRIK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2376122-A2 | AGENT FOR PROPHYLAXIS OR TREATMENT OF CANCER | Takeda Pharmaceutical Company Limited (JP) | 2011-10-19 | — | — | EP | disclosed |
| WO-2010079850-A2 | AGENT FOR PROPHYLAXIS OR TREATMENT OF CANCER | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-07-15 | — | — | WO | disclosed |
| US-7718404-B2 | α-isomaltosylglucosaccharide-forming enzyme, process and uses of the same | KABUSHIKI KAISHA HAYASHIBARA SEIBUTSU KAGAKU KENKYUJO (JP) | 2010-05-18 | — | — | US | disclosed |
| US-20080003651-A1 | alpha-isomaltosylglucosaccharide-forming enzyme, process and uses of the same | KABUSHIKI KAISHA HAYASHIBARA SEIBUTSU KAGAKU KENKYUJO (JP) | 2008-01-03 | — | — | US | disclosed |
| US-5900476-A | MUTANT POLYPEPTIDE WITHOUT CYSTEINES, OR MODIFIED TO PREVENT DISULFIDE BOND FORMATION SUPPRESSES BINDING OF FACTOR TO PLATELETS; ANTITHROMBOSIS AGENTS | THE SCRIPPS RESEARCH INSTITUTE (US) | 1999-05-04 | — | — | US | disclosed |
| US-5847086-A | Therapeutic fragments of von Willebrand factor | CENTEON L.L.C. (US) | 1998-12-08 | — | — | US | disclosed |
| US-5539086-A | CYSTEINE ALTERED FRAGMENTS FOR PURIFICATION, DENATURING, AGGREGATION AND SEPARATION | Rh one-Poulenc Rorer Pharmaceuticals Inc. (US) | 1996-07-23 | — | — | US | disclosed |