Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | XBP1 | P17861 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.37 |
| ▸ | MEN1 | O00255 | 4/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.36 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24846120 | 0.94 | GAA (0.41) | SMN1; SMN2GAAMAPTXBP1NPSR1 | |
| SCHEMBL24846671 | 0.93 | DGAT1 (0.40) | SMN1; SMN2GAAMAPTXBP1NPSR1 | |
| SCHEMBL24846112 | 0.90 | KMT2A (0.37) | SMN1; SMN2GAAMAPTXBP1NPSR1 | |
| SCHEMBL24846603 | 0.90 | SMN1; SMN2 (0.39) | SMN1; SMN2L3MBTL1KMT2AMEN1CYP1A2 | |
| SCHEMBL24846680 | 0.89 | SMN1; SMN2 (0.37) | SMN1; SMN2GAAMAPTXBP1NPSR1 | |
| SCHEMBL24846091 | 0.87 | SMN1; SMN2 (0.44) | SMN1; SMN2GAAMAPTXBP1NPSR1 | |
| SCHEMBL24846064 | 0.86 | KMT2A (0.47) | SMN1; SMN2GAAMAPTXBP1NPSR1 | |
| SCHEMBL24846067 | 0.84 | SMN1; SMN2 (0.39) | SMN1; SMN2L3MBTL1KMT2AMEN1CYP1A2 | |
| SCHEMBL24846672 | 0.83 | SMN1; SMN2 (0.42) | SMN1; SMN2MAPTL3MBTL1ALDH1A1KMT2A | |
| SCHEMBL24846095 | 0.83 | DGAT1 (0.42) | MAPTALDH1A1KMT2AMEN1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230002336-A1 | MrgprX2 Antagonists and Uses Thereof | DERMIRA, INC. | 2023-01-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230002336-A1 | MrgprX2 Antagonists and Uses Thereof | MRGPRX2, MRGPRX1, MRGPRX4 | SMN1; SMN2 4282/4885GAA 709/4885MAPT 4012/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.