Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.75 |
| ▸ | GLA | P06280 | 1/20 | 0.75 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.75 |
| ▸ | MAPT | P10636 | 1/20 | 0.71 |
| ▸ | PKM | P14618 | 1/20 | 0.71 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.61 |
| ▸ | NPC1 | O15118 | 1/20 | 0.61 |
| ▸ | RAB9A | P51151 | 1/20 | 0.61 |
| ▸ | PIM1 | P11309 | 11/20 | 0.55 |
| ▸ | CSNK2A2 | P19784 | 11/20 | 0.55 |
| ▸ | CSNK2B | P67870 | 11/20 | 0.55 |
| ▸ | PIM3 | Q86V86 | 11/20 | 0.55 |
| ▸ | PIM2 | Q9P1W9 | 11/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30080447 | 1.00 | ALDH1A1 (0.75) | ALDH1A1GLAL3MBTL1MAPTPKM | |
| SCHEMBL1855348 | 0.86 | ALDH1A1 (0.75) | ALDH1A1GLAL3MBTL1MAPTPKM | |
| SCHEMBL20667972 | 0.86 | ALDH1A1 (1.00) | ALDH1A1GLAL3MBTL1MAPTPKM | |
| SCHEMBL4098050 | 0.82 | ALDH1A1 (0.74) | ALDH1A1GLAL3MBTL1MAPTPKM | |
| SCHEMBL30914113 | 0.79 | ALDH1A1 (0.68) | ALDH1A1GLAL3MBTL1MAPTPKM | |
| SCHEMBL27238675 | 0.79 | ALDH1A1 (0.68) | ALDH1A1GLAL3MBTL1MAPTPKM | |
| SCHEMBL4273392 | 0.78 | ALDH1A1 (0.63) | ALDH1A1GLAL3MBTL1MAPTPKM | |
| SCHEMBL15304529 | 0.78 | ALDH1A1 (0.68) | ALDH1A1GLAL3MBTL1MAPTPKM | |
| SCHEMBL30914158 | 0.77 | ALDH1A1 (0.62) | ALDH1A1GLAL3MBTL1MAPTPKM | |
| SCHEMBL1852454 | 0.76 | PIM1 (0.75) | ALDH1A1GLAL3MBTL1MAPTPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4337326-A1 | PYRIDINE DERIVATIVES WITH N-LINKED CYCLIC SUBSTITUENTS AS CGAS INHIBITORS | Boehringer Ingelheim International GmbH (DE) | 2024-03-20 | — | — | EP | disclosed |
| US-20230000878-A1 | PYRIDINE DERIVATIVES WITH N-LINKED CYCLIC SUBSTITUENTS AS cGAS INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2023-01-05 | — | — | US | disclosed |
| WO-2022238327-A1 | PYRIDINE DERIVATIVES WITH N-LINKED CYCLIC SUBSTITUENTS AS CGAS INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2022-11-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230000878-A1 | PYRIDINE DERIVATIVES WITH N-LINKED CYCLIC SUBSTITUENTS AS cGAS INHIBITORS | CGAS, GLS2, GMPS | ALDH1A1 1112/4885GLA 873/4885L3MBTL1 1962/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.