Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.63 |
| ▸ | GLA | P06280 | 1/20 | 0.63 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.63 |
| ▸ | MAPT | P10636 | 1/20 | 0.60 |
| ▸ | PKM | P14618 | 1/20 | 0.60 |
| ▸ | CSNK2B | P67870 | 12/20 | 0.59 |
| ▸ | PIM1 | P11309 | 12/20 | 0.59 |
| ▸ | CSNK2A2 | P19784 | 10/20 | 0.59 |
| ▸ | PIM3 | Q86V86 | 10/20 | 0.59 |
| ▸ | PIM2 | Q9P1W9 | 9/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | CSNK2A1 | P68400 | 4/20 | 0.46 |
| ▸ | CDC7 | O00311 | 3/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15304529 | 0.81 | ALDH1A1 (0.68) | ALDH1A1GLAL3MBTL1MAPTPKM | |
| SCHEMBL1855348 | 0.78 | ALDH1A1 (0.75) | ALDH1A1GLAL3MBTL1MAPTPKM | |
| SCHEMBL20667972 | 0.78 | ALDH1A1 (1.00) | ALDH1A1GLAL3MBTL1MAPTPKM | |
| SCHEMBL24847196 | 0.78 | ALDH1A1 (0.75) | ALDH1A1GLAL3MBTL1MAPTPKM | |
| SCHEMBL30080447 | 0.78 | ALDH1A1 (0.75) | ALDH1A1GLAL3MBTL1MAPTPKM | |
| SCHEMBL4098050 | 0.75 | ALDH1A1 (0.74) | ALDH1A1GLAL3MBTL1MAPTPKM | |
| SCHEMBL30914113 | 0.72 | ALDH1A1 (0.68) | ALDH1A1GLAL3MBTL1MAPTPKM | |
| SCHEMBL2219360 | 0.72 | PIM1 (0.60) | ALDH1A1GLAL3MBTL1MAPTPKM | |
| SCHEMBL1857738 | 0.71 | KDM4E (1.00) | ALDH1A1GLAL3MBTL1MAPTPKM | |
| SCHEMBL1852188 | 0.71 | PIM1 (0.72) | ALDH1A1GLAL3MBTL1MAPTPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2097419-A1 | BENZOFUROPYRIMIDINONES AS PROTEIN KINASE INHIBITORS | Exelixis, Inc. (US) | 2009-09-09 | — | — | EP | disclosed |
| WO-2009086264-A1 | BENZOFUROPYRIMIDINONES AS PROTEIN KINASE INHIBITORS | EXELIXIS, INC. (US) | 2009-07-09 | — | — | WO | disclosed |