SCHEMBL2484725

SCHEMBL2484725

NC(=O)c1c(-c2ccccc2C(F)(F)F)cccc1C(F)(F)F

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PARP1 P09874 1/20 0.49
SCN9A Q15858 5/20 0.47
ALDH1A1 P00352 1/20 0.46
HPGD P15428 1/20 0.46
SLC9A1 P19634 1/20 0.46
SCN10A Q9Y5Y9 1/20 0.45
AKR1C3 P42330 1/20 0.42
AKR1C2 P52895 1/20 0.42
KMO O15229 2/20 0.42
MAOB P27338 1/20 0.41
LMNA P02545 1/20 0.41
GAA P10253 1/20 0.41
CDC7 O00311 1/20 0.40
CCNE1 P24864 1/20 0.40
CDK2 P24941 1/20 0.40
DBF4 Q9UBU7 1/20 0.40
PDK2 Q15119 2/20 0.40
ELANE P08246 1/20 0.40
HSD11B1 P28845 1/20 0.40
NFKB1 P19838 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6677946 0.88 BCAT2 (0.49) PARP1SCN9AALDH1A1HPGDSLC9A1
SCHEMBL29978674 0.88 BCAT2 (0.49) PARP1SCN9AALDH1A1HPGDSLC9A1
SCHEMBL7878426 0.86 MAOB (0.42) PARP1SCN9AALDH1A1HPGDSLC9A1
SCHEMBL5143960 0.81 PARP1 (0.56) PARP1SCN9AALDH1A1HPGDSLC9A1
SCHEMBL30608075 0.81 PARP1 (0.56) PARP1SCN9AALDH1A1HPGDSLC9A1
SCHEMBL4776527 0.80 PARP1 (0.54) PARP1SCN9AALDH1A1HPGDSLC9A1
SCHEMBL29733181 0.80 PARP1 (0.58) PARP1SCN9AALDH1A1HPGDSLC9A1
SCHEMBL4095197 0.79 PTGS1 (0.39) PARP1SCN9AALDH1A1HPGDSLC9A1
SCHEMBL3716117 0.79 CA12 (0.43) PARP1SCN9AALDH1A1HPGDSLC9A1
SCHEMBL3708513 0.79 CES2 (0.48) PARP1SCN9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2375904-A1 BIARYL CARBOXAMIDES Merck Sharp & Dohme Corp. (US) 2011-10-19 EP claimed
WO-2010077624-A1 BIARYL CARBOXAMIDES MERCK SHARP & DOHME CORP. (US) 2010-07-08 WO claimed