Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | PAOX | Q6QHF9 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
| ▸ | GBA1 | P04062 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25730066 | 0.98 | ALDH1A1 (0.43) | ALDH1A1KDM4EUSP2HPGDTDP1 | |
| SCHEMBL21015382 | 0.93 | ALDH1A1 (0.42) | ALDH1A1KDM4EUSP2HPGDPAOX | |
| SCHEMBL25111304 | 0.93 | ALDH1A1 (0.44) | ALDH1A1KDM4EUSP2HPGDPAOX | |
| SCHEMBL24060966 | 0.87 | ALDH1A1 (0.45) | ALDH1A1KDM4EUSP2HPGDTDP1 | |
| SCHEMBL21455987 | 0.86 | KDM4E (0.34) | ALDH1A1KDM4ETDP1HRH3NPC1 | |
| SCHEMBL26445210 | 0.86 | MAOB (0.39) | ALDH1A1KDM4EHRH3HTT | |
| SCHEMBL24673304 | 0.86 | HRH3 (0.35) | USP2HRH3GBA1HTT | |
| SCHEMBL21106253 | 0.86 | HRH2 (0.39) | ALDH1A1KDM4ERAB9ANPC1GBA1 | |
| SCHEMBL21016113 | 0.86 | HSD11B1 (0.35) | ALDH1A1KDM4EHRH3NPC1GBA1 | |
| SCHEMBL22848922 | 0.86 | MAPK1 (0.39) | ALDH1A1KDM4ETDP1RAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023278759-A1 | MK2 DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2023-01-05 | — | — | WO | disclosed |