Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPA1 | P27694 | 1/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 4/20 | 0.38 |
| ▸ | CUL4A | Q13619 | 3/20 | 0.36 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.35 |
| ▸ | PGR | P06401 | 1/20 | 0.35 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.35 |
| ▸ | AR | P10275 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | TSPO | P30536 | 1/20 | 0.35 |
| ▸ | PTPRC | P08575 | 1/20 | 0.35 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.35 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.35 |
| ▸ | PTPA | Q15257 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | KMO | O15229 | 1/20 | 0.34 |
| ▸ | CASP1 | P29466 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2482175 | 0.84 | CUL4A (0.39) | CUL4AALDH1A1NPC1MAPTRAB9A | |
| SCHEMBL2485581 | 0.84 | ALOX5 (0.47) | ALOX5CUL4AALDH1A1MAPT | |
| SCHEMBL2484122 | 0.82 | XPO1 (0.36) | RPA1ALOX5CUL4APGRALDH1A1 | |
| SCHEMBL418485 | 0.81 | MAOB (0.44) | RPA1ALOX5ALDH1A1PTPRCPTPN2 | |
| SCHEMBL2509896 | 0.78 | PGR (0.42) | RPA1ALOX5NR3C1PGRNR3C2 | |
| SCHEMBL2510358 | 0.74 | CNR2 (0.44) | ALOX5CUL4APGRPOLB | |
| SCHEMBL8232745 | 0.73 | ABL1 (0.39) | ALOX5CUL4ATSPOPTPRCPTPN2 | |
| SCHEMBL2486696 | 0.72 | CUL4A (0.47) | CUL4AALDH1A1TSHRMAOBPOLB | |
| SCHEMBL2487648 | 0.70 | ALOX5 (0.41) | ALOX5ALDH1A1MAPTCHRM3 | |
| SCHEMBL15620632 | 0.68 | ALOX5 (0.40) | RPA1ALOX5ALDH1A1PTPRCPTPN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2376479-B1 | SUBSTITUTED FURANCARBOXAMIDES, AND USE THEREOF | AICURIS GMBH & CO KG (DE) | 2016-03-02 | — | — | EP | disclosed |
| EP-2376479-A1 | SUBSTITUTED FURANCARBOXAMIDES, AND USE THEREOF | AiCuris GmbH & Co. KG (DE) | 2011-10-19 | — | — | EP | disclosed |
| WO-2010075957-A1 | SUBSTITUTED FURANCARBOXAMIDES, AND USE THEREOF | AICURIS GMBH & CO. KG (DE) | 2010-07-08 | — | — | WO | disclosed |