Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K4 | P45985 | 2/20 | 0.43 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.41 |
| ▸ | C5AR1 | P21730 | 2/20 | 0.39 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.39 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.39 |
| ▸ | F12 | P00748 | 3/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.39 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.39 |
| ▸ | KIT | P10721 | 2/20 | 0.39 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.37 |
| ▸ | UCHL1 | P09936 | 2/20 | 0.37 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.37 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2487774 | 0.88 | CKS1B (0.47) | PARP1TNKS2PARP2KITHDAC1 | |
| SCHEMBL2488516 | 0.86 | BTK (0.40) | C5AR1PARP1TNKS2PARP2KIT | |
| SCHEMBL2484169 | 0.84 | ROCK2 (0.46) | F12PARP1TNKS2PARP2HDAC1 | |
| SCHEMBL2490202 | 0.80 | PARP1 (0.43) | C5AR1F12PARP1TNKS2PARP2 | |
| SCHEMBL2485087 | 0.77 | NR1H2 (0.41) | MAP2K4PARP14CSNK1DCSNK1EPARP1 | |
| SCHEMBL2487131 | 0.77 | IDO1 (0.42) | PARP1TNKS2PARP2CRBNHDAC1 | |
| SCHEMBL1785437 | 0.71 | ESR2 (0.61) | MAP2K4PARP14C5AR1CRBNHDAC6 | |
| SCHEMBL2486452 | 0.71 | NR1H2 (0.51) | F12PARP1TNKS2PARP2CRBN | |
| SCHEMBL31747276 | 0.69 | PDK4 (0.54) | MAP2K4PARP14 | |
| SCHEMBL22478122 | 0.68 | FLT3 (0.44) | PARP1TNKS2PARP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2379551-A1 | SUBSTITUTED PYRAZOLO [3, 4-B]PYRIDINE COMPOUNDS | ArQule, Inc. (US) | 2011-10-26 | — | — | EP | disclosed |
| WO-2010078427-A1 | SUBSTITUTED PYRAZOLO [3, 4-B] PYRIDINE COMPOUNDS | ARQULE, INC. (US) | 2010-07-08 | — | — | WO | disclosed |