Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CKS1B | P61024 | 2/20 | 0.47 |
| ▸ | SKP1 | P63208 | 2/20 | 0.47 |
| ▸ | SKP2 | Q13309 | 2/20 | 0.47 |
| ▸ | KIT | P10721 | 1/20 | 0.43 |
| ▸ | UCHL1 | P09936 | 2/20 | 0.42 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.41 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.41 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | ACKR3 | P25106 | 2/20 | 0.40 |
| ▸ | GBA1 | P04062 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | RORC | P51449 | 2/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2490202 | 0.88 | PARP1 (0.43) | UCHL1PARP1TNKS2PARP2MAPK1 | |
| SCHEMBL2485090 | 0.88 | MAP2K4 (0.43) | KITUCHL1PARP1TNKS2PARP2 | |
| SCHEMBL2488516 | 0.87 | BTK (0.40) | KITPARP1TNKS2PARP2BRD4 | |
| SCHEMBL2484169 | 0.85 | ROCK2 (0.46) | PARP1TNKS2PARP2USP30ACKR3 | |
| SCHEMBL2487131 | 0.83 | IDO1 (0.42) | PARP1TNKS2PARP2HDAC1HDAC6 | |
| SCHEMBL10095067 | 0.76 | BRD4 (0.67) | CKS1BSKP1SKP2LMNAMAPK1 | |
| SCHEMBL2486452 | 0.76 | NR1H2 (0.51) | PARP1TNKS2PARP2MAPK1 | |
| SCHEMBL2488053 | 0.76 | GLS (0.44) | CKS1BSKP1SKP2KITPARP1 | |
| SCHEMBL14328064 | 0.75 | P2RX7 (0.49) | CKS1BSKP1SKP2UCHL1PARP1 | |
| SCHEMBL2486158 | 0.74 | CREBBP (0.36) | LMNABRD4CREBBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2379551-A1 | SUBSTITUTED PYRAZOLO [3, 4-B]PYRIDINE COMPOUNDS | ArQule, Inc. (US) | 2011-10-26 | — | — | EP | disclosed |
| WO-2010078427-A1 | SUBSTITUTED PYRAZOLO [3, 4-B] PYRIDINE COMPOUNDS | ARQULE, INC. (US) | 2010-07-08 | — | — | WO | disclosed |