Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GUSB | P08236 | 3/20 | 0.47 |
| ▸ | IL4I1 | Q96RQ9 | 5/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.43 |
| ▸ | EGFR | P00533 | 4/20 | 0.42 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24852506 | 0.82 | KDM4E (0.46) | GUSBIL4I1KDM4EEGFRERBB2 | |
| SCHEMBL24852000 | 0.80 | EGFR (0.55) | GUSBIL4I1EGFRERBB2ALDH1A1 | |
| SCHEMBL24852507 | 0.80 | IL4I1 (0.51) | IL4I1KDM4EEGFRMEN1KMT2A | |
| SCHEMBL24851909 | 0.80 | GUSB (0.45) | GUSBIL4I1KDM4EEGFRERBB2 | |
| SCHEMBL24852500 | 0.79 | GUSB (0.44) | GUSBIL4I1KDM4EEGFRERBB2 | |
| SCHEMBL24852006 | 0.78 | EGFR (0.52) | GUSBIL4I1EGFRERBB2HPGD | |
| SCHEMBL24852502 | 0.78 | KDM4E (0.45) | IL4I1KDM4EEGFRMEN1KMT2A | |
| SCHEMBL24851962 | 0.77 | IL4I1 (0.51) | IL4I1KDM4EEGFRERBB2ALDH1A1 | |
| SCHEMBL24852045 | 0.77 | IL4I1 (0.43) | GUSBIL4I1KDM4EEGFRERBB2 | |
| SCHEMBL24852002 | 0.77 | IL4I1 (0.44) | GUSBIL4I1KDM4EEGFRERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023278222-A1 | IL4I1 INHIBITORS AND METHODS OF USE | MERCK SHARP & DOHME LLC (US) | 2023-01-05 | — | — | WO | disclosed |