Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 6/20 | 0.55 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.55 |
| ▸ | GUSB | P08236 | 3/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.50 |
| ▸ | IL4I1 | Q96RQ9 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | PIP4K2A | P48426 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24852013 | 0.88 | GUSB (0.48) | EGFRERBB2GUSBHPGDIL4I1 | |
| SCHEMBL24852005 | 0.86 | GUSB (0.47) | EGFRERBB2GUSBTSHRIL4I1 | |
| SCHEMBL24851794 | 0.86 | GUSB (0.47) | EGFRERBB2GUSBHPGDNPC1 | |
| SCHEMBL24851924 | 0.85 | GUSB (0.46) | EGFRERBB2GUSBHPGDTSHR | |
| SCHEMBL24851999 | 0.83 | GUSB (0.56) | EGFRERBB2GUSBHPGDIL4I1 | |
| SCHEMBL24852507 | 0.82 | IL4I1 (0.51) | EGFRHPGDTSHRSMN1; SMN2IL4I1 | |
| SCHEMBL24851962 | 0.82 | IL4I1 (0.51) | EGFRERBB2HPGDTSHRSMN1; SMN2 | |
| SCHEMBL24852002 | 0.82 | IL4I1 (0.44) | EGFRERBB2GUSBHPGDTSHR | |
| SCHEMBL24852506 | 0.81 | KDM4E (0.46) | EGFRERBB2GUSBHPGDIL4I1 | |
| SCHEMBL24852008 | 0.80 | GUSB (0.51) | EGFRERBB2GUSBHPGDIL4I1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023278222-A1 | IL4I1 INHIBITORS AND METHODS OF USE | MERCK SHARP & DOHME LLC (US) | 2023-01-05 | — | — | WO | disclosed |