Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | IL4I1 | Q96RQ9 | 6/20 | 0.46 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.45 |
| ▸ | IDH1 | O75874 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24851742 | 0.85 | KDM4E (0.46) | KDM4EALDH1A1HPGDIL4I1PDE10A | |
| SCHEMBL30162767 | 0.85 | KDM4E (0.46) | KDM4EALDH1A1HPGDIL4I1PDE10A | |
| SCHEMBL30162577 | 0.85 | IL4I1 (0.51) | KDM4EALDH1A1HPGDIL4I1PDE10A | |
| SCHEMBL24852688 | 0.85 | IL4I1 (0.51) | KDM4EALDH1A1HPGDIL4I1PDE10A | |
| SCHEMBL24851981 | 0.83 | IL4I1 (0.51) | KDM4EALDH1A1HPGDIL4I1PDE10A | |
| SCHEMBL30162723 | 0.83 | IL4I1 (0.51) | KDM4EALDH1A1HPGDIL4I1PDE10A | |
| SCHEMBL24851966 | 0.75 | IL4I1 (0.51) | KDM4EALDH1A1HPGDIL4I1IDH1 | |
| SCHEMBL24851723 | 0.73 | IL4I1 (0.51) | KDM4EALDH1A1HPGDIL4I1PDE10A | |
| SCHEMBL24852514 | 0.69 | IL4I1 (0.57) | KDM4EALDH1A1HPGDIL4I1HSD17B10 | |
| SCHEMBL30162565 | 0.69 | IL4I1 (0.57) | KDM4EALDH1A1HPGDIL4I1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023278222-A1 | IL4I1 INHIBITORS AND METHODS OF USE | MERCK SHARP & DOHME LLC (US) | 2023-01-05 | — | — | WO | disclosed |