Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IL4I1 | Q96RQ9 | 6/20 | 0.51 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | IDH1 | O75874 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30162723 | 1.00 | IL4I1 (0.51) | IL4I1PDE10AKDM4EALDH1A1HPGD | |
| SCHEMBL24851978 | 0.83 | KDM4E (0.46) | IL4I1PDE10AKDM4EALDH1A1HPGD | |
| SCHEMBL30162577 | 0.82 | IL4I1 (0.51) | IL4I1PDE10AKDM4EALDH1A1HPGD | |
| SCHEMBL24851742 | 0.82 | KDM4E (0.46) | IL4I1PDE10AKDM4EALDH1A1HPGD | |
| SCHEMBL30162767 | 0.82 | KDM4E (0.46) | IL4I1PDE10AKDM4EALDH1A1HPGD | |
| SCHEMBL24852688 | 0.82 | IL4I1 (0.51) | IL4I1PDE10AKDM4EALDH1A1HPGD | |
| SCHEMBL24852147 | 0.75 | IL4I1 (0.56) | IL4I1KDM4EALDH1A1HPGDTSHR | |
| SCHEMBL24852069 | 0.75 | IL4I1 (0.52) | IL4I1PDE10AKDM4EALDH1A1HPGD | |
| SCHEMBL24852514 | 0.74 | IL4I1 (0.57) | IL4I1KDM4EALDH1A1HPGDTSHR | |
| SCHEMBL30162565 | 0.74 | IL4I1 (0.57) | IL4I1KDM4EALDH1A1HPGDTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023278222-A1 | IL4I1 INHIBITORS AND METHODS OF USE | MERCK SHARP & DOHME LLC (US) | 2023-01-05 | — | — | WO | disclosed |