Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IL4I1 | Q96RQ9 | 6/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | APAF1 | O14727 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31192193 | 1.00 | IL4I1 (0.52) | IL4I1ALDH1A1KDM4ETSHRCYP3A4 | |
| SCHEMBL24852634 | 0.84 | IL4I1 (0.54) | IL4I1ALDH1A1KDM4ETSHRCYP3A4 | |
| SCHEMBL30162602 | 0.84 | IL4I1 (0.54) | IL4I1ALDH1A1KDM4ETSHRCYP3A4 | |
| SCHEMBL24851998 | 0.77 | CD274 (0.42) | — | |
| SCHEMBL24852514 | 0.75 | IL4I1 (0.57) | IL4I1ALDH1A1KDM4ETSHRHPGD | |
| SCHEMBL30162565 | 0.75 | IL4I1 (0.57) | IL4I1ALDH1A1KDM4ETSHRHPGD | |
| SCHEMBL24852992 | 0.71 | IL4I1 (0.53) | IL4I1ALDH1A1KDM4ETSHRHPGD | |
| SCHEMBL24852651 | 0.70 | IL4I1 (0.55) | IL4I1ALDH1A1KDM4ETSHRHPGD | |
| SCHEMBL24852060 | 0.69 | IL4I1 (0.64) | IL4I1ALDH1A1KDM4ECYP2C9CYP2C19 | |
| SCHEMBL14458002 | 0.69 | SRD5A1 (0.52) | ALDH1A1KDM4ETSHRCYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023278222-A1 | IL4I1 INHIBITORS AND METHODS OF USE | MERCK SHARP & DOHME LLC (US) | 2023-01-05 | — | — | WO | disclosed |