Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IL4I1 | Q96RQ9 | 6/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.39 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | APAF1 | O14727 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24852634 | 1.00 | IL4I1 (0.54) | IL4I1ALDH1A1TSHRCYP3A4CYP2C9 | |
| SCHEMBL24851997 | 0.84 | IL4I1 (0.52) | IL4I1ALDH1A1TSHRCYP3A4CYP2C9 | |
| SCHEMBL31192193 | 0.84 | IL4I1 (0.52) | IL4I1ALDH1A1TSHRCYP3A4CYP2C9 | |
| SCHEMBL24851945 | 0.78 | IL4I1 (0.56) | IL4I1ALDH1A1TSHRCYP3A4CYP2C9 | |
| SCHEMBL24851942 | 0.77 | IL4I1 (0.50) | IL4I1ALDH1A1TSHRCYP3A4CYP2C9 | |
| SCHEMBL24852549 | 0.77 | IL4I1 (0.52) | IL4I1ALDH1A1TSHRCYP3A4CYP2C9 | |
| SCHEMBL24852748 | 0.77 | IL4I1 (0.52) | IL4I1ALDH1A1TSHRCYP3A4CYP2C9 | |
| SCHEMBL24852548 | 0.77 | IL4I1 (0.52) | IL4I1ALDH1A1TSHRCYP3A4CYP2C9 | |
| SCHEMBL24852579 | 0.76 | IL4I1 (0.51) | IL4I1ALDH1A1TSHRCYP3A4CYP2C9 | |
| SCHEMBL31192211 | 0.75 | PDE4A (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4362978-A1 | IL4I1 INHIBITORS AND METHODS OF USE | Merck Sharp & Dohme LLC (US) | 2024-05-08 | — | — | EP | disclosed |
| WO-2023278222-A1 | IL4I1 INHIBITORS AND METHODS OF USE | MERCK SHARP & DOHME LLC (US) | 2023-01-05 | — | — | WO | disclosed |