Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | ATAD2 | Q6PL18 | 9/20 | 0.42 |
| ▸ | CECR2 | Q9BXF3 | 8/20 | 0.42 |
| ▸ | BRD4 | O60885 | 3/20 | 0.42 |
| ▸ | GSK3A | P49840 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4597653 | 0.78 | TSHR (1.00) | TSHRALDH1A1POLBGSK3AGSK3B | |
| SCHEMBL13629854 | 0.76 | TSHR (0.68) | TSHRALDH1A1POLBATAD2CECR2 | |
| SCHEMBL6773573 | 0.76 | TSHR (0.61) | TSHRALDH1A1POLBATAD2CECR2 | |
| SCHEMBL12177294 | 0.75 | ALDH1A1 (0.69) | TSHRALDH1A1POLBATAD2CECR2 | |
| SCHEMBL12177434 | 0.74 | ALDH1A1 (0.71) | ALDH1A1ATAD2CECR2BRD4 | |
| SCHEMBL20393489 | 0.73 | TSHR (0.63) | TSHRALDH1A1POLBATAD2CECR2 | |
| SCHEMBL7454709 | 0.73 | TSHR (0.63) | TSHRALDH1A1POLBATAD2CECR2 | |
| SCHEMBL12177211 | 0.73 | ALDH1A1 (0.74) | ALDH1A1POLBATAD2CECR2BRD4 | |
| SCHEMBL1406517 | 0.70 | — | — | |
| SCHEMBL2527934 | 0.70 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8022092-B2 | (2,5-dioxoimidazolidin-1-yl)-N-hydroxy-acetamides as metalloproteinase inhibitors | MEDIVIR AB (SE) | 2011-09-20 | — | — | US | disclosed |