Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER4 | P35408 | 17/20 | 0.72 |
| ▸ | PTGER2 | P43116 | 3/20 | 0.58 |
| ▸ | PHGDH | O43175 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24861730 | 1.00 | PTGER4 (0.72) | PTGER4PTGER2PHGDHLMNANPSR1 | |
| SCHEMBL24861972 | 0.92 | PTGER4 (0.61) | PTGER4PTGER2PHGDHLMNANPSR1 | |
| SCHEMBL24861973 | 0.92 | PTGER4 (0.61) | PTGER4PTGER2PHGDHLMNANPSR1 | |
| SCHEMBL26417363 | 0.91 | PTGER4 (0.72) | PTGER4PTGER2PHGDH | |
| SCHEMBL28709264 | 0.90 | PTGER4 (0.59) | PTGER4PTGER2PHGDHLMNANPSR1 | |
| SCHEMBL26417331 | 0.90 | PTGER4 (0.72) | PTGER4PTGER2PHGDH | |
| SCHEMBL24861880 | 0.90 | PTGER4 (0.72) | PTGER4PTGER2PHGDH | |
| SCHEMBL24861731 | 0.89 | PTGER4 (0.57) | PTGER4PTGER2PHGDHLMNANPSR1 | |
| SCHEMBL881502 | 0.85 | PTGER4 (0.77) | PTGER4PTGER2 | |
| SCHEMBL26416555 | 0.84 | PTGER4 (0.62) | PTGER4PTGER2PHGDH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4116291-A1 | SYNTHESIS OF NOVEL EP4 ANTAGONIST AND USE IN CANCERS AND INFLAMMATIONS | Wuhan Humanwell Innovative Drug Research and Development Center Limited Company (CN) | 2023-01-11 | — | — | EP | disclosed |
| CN-113354585-A | Synthesis of novel EP4 antagonists and their use in cancer and inflammation | 湖北生物医药产业技术研究院有限公司 | 2021-09-07 | — | — | CN | disclosed |