SCHEMBL24861815 — predicted protein targets

Predicted protein targets (top 8)

	gene	UniProt	supporting neighbours	confidence
▸	JAK2	O60674	1/20	0.33

▸	JAK1	P23458	1/20	0.33

▸	TYK2	P29597	1/20	0.33

▸	JAK3	P52333	1/20	0.33

▸	ALDH1A1	P00352	1/20	0.33

▸	HTT	P42858	1/20	0.33

▸	SMN1; SMN2	Q16637	1/20	0.33

▸	L3MBTL1	Q9Y468	1/20	0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL20909570	0.89	ESR1 (0.31)	JAK2JAK1TYK2JAK3
SCHEMBL23429889	0.86	ALDH1A1 (0.31)	ALDH1A1HTTSMN1; SMN2L3MBTL1
SCHEMBL19176085	0.83	JAK2 (0.35)	JAK2JAK1TYK2JAK3ALDH1A1
SCHEMBL21449540	0.83	CNR1 (0.32)	JAK2JAK1TYK2JAK3
SCHEMBL22215355	0.83	CNR1 (0.32)	JAK2JAK1TYK2JAK3
SCHEMBL23429763	0.81	ALDH1A1 (0.33)	ALDH1A1HTTSMN1; SMN2L3MBTL1
SCHEMBL17018460	0.80	ALDH1A1 (0.34)	JAK2JAK1TYK2JAK3ALDH1A1
SCHEMBL22952619	0.79	L3MBTL1 (0.46)	ALDH1A1L3MBTL1
SCHEMBL23583957	0.78	CNR1 (0.33)	ALDH1A1HTTSMN1; SMN2L3MBTL1
SCHEMBL22273334	0.78	CNR1 (0.33)	ALDH1A1HTTSMN1; SMN2L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
EP-3694858-B1	BICYCLIC COMPOUNDS FOR USE AS RIP1 KINASE INHIBITORS	HOFFMANN LA ROCHE (CH)	2023-01-11	—	—	EP	disclosed