SCHEMBL248619

SCHEMBL248619

Cn1c(=O)ccc2ccccc21

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
BRPF1 P55201 8/20 1.00
BRD4 O60885 3/20 1.00
BRD9 Q9H8M2 3/20 1.00
CA12 O43570 2/20 1.00
CA9 Q16790 2/20 1.00
KAT2B Q92831 1/20 1.00
ALDH1A1 P00352 1/20 0.57
MAPT P10636 1/20 0.57
DAO P14920 1/20 0.50
BRD1 O95696 3/20 0.47
BRPF3 Q9ULD4 1/20 0.47
KDM4E B2RXH2 1/20 0.47
NQO2 P16083 1/20 0.47
PRKD3 O94806 1/20 0.46
PRKCG P05129 1/20 0.46
PRKCB P05771 1/20 0.46
PRKCA P17252 1/20 0.46
PRKACA P17612 1/20 0.46
PRKACG P22612 1/20 0.46
PRKACB P22694 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29967380 1.00 BRPF1 (1.00) BRPF1BRD4BRD9CA12CA9
Hydrochloric Acid SCHEMBL1236989 0.98 BRPF1 (0.96) BRPF1BRD4BRD9CA12CA9
Hydrochloric Acid SCHEMBL30419636 0.98 BRPF1 (0.96) BRPF1BRD4BRD9CA12CA9
Hydrochloric Acid SCHEMBL7218030 0.96 BRPF1 (0.92) BRPF1BRD4BRD9CA12CA9
Bicarbonate SCHEMBL10970799 0.92 BRPF1 (0.85) BRPF1BRD4BRD9CA12CA9
Pyridine SCHEMBL11505119 0.87 BRPF1 (0.76) BRPF1BRD4BRD9CA12CA9
SCHEMBL10489571 0.79 BRPF1 (0.63) BRPF1BRD4BRD9CA12CA9
SCHEMBL8944339 0.78 BRPF1 (0.63) BRPF1BRD4BRD9CA12CA9
SCHEMBL271495 0.77 CA12 (0.63) BRPF1BRD4BRD9CA12CA9
SCHEMBL31743122 0.77 BRPF1 (0.61) BRPF1BRD4BRD9CA12CA9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 644 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260124198-A1 ANTIVIRAL PYRAZOLOPYRIDINONE COMPOUNDS GILEAD SCIENCES INC (US) 2026-05-07 US claimed
CN-117510407-A Visible light catalyzed olefin hydrogenation and deuteration method 瑞博(苏州)制药有限公司 2024-02-06 CN claimed
US-11286240-B2 Catalyst bound alpha radical and synthesis of OXO compounds using the same COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) 2022-03-29 US claimed
US-20210147364-A1 A CATALYST BOUND ALPHA RADICAL AND SYNTHESIS OF OXO COMPOUNDS USING THE SAME COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) 2021-05-20 US claimed
CN-109078656-B Preparation method of aluminum chloride-loaded methylphenol isomerization catalyst 西安元创化工科技股份有限公司 2021-05-14 CN claimed
EP-3542801-A1 PURIN DERIVATIVES FOR USE IN THE TREATMENT OF FAP-RELATED DISEASES Boehringer Ingelheim International GmbH (DE) 2019-09-25 EP claimed
CN-109078656-A A kind of preparation method for the sylvan isomerization catalyst loading aluminium chloride 西安元创化工科技股份有限公司 2018-12-25 CN claimed
CN-108239027-A The synthetic method of pharmaceutical intermediate 1- methyl -2- quinolinones 成都卡迪夫科技有限公司 2018-07-03 CN claimed
CN-105001222-B 8 [base of 3 amino piperidine 1] Xanthine compounds, its preparation method and purposes as pharmaceutical preparation 勃林格殷格翰制药两合公司 2017-11-07 CN claimed
US-20160368906-A1 BICYCLIC HETEROCYCLIC DERIVATIVES AS BROMODOMAIN INHIBITORS ORION CORPORATION (FI) 2016-12-22 US claimed
WO-2001064246-A2 FARNESYL PROTEIN TRANSFERASE INHIBITOR COMBINATIONS WITH AN HER2 ANTIBODY JANSSEN PHARMACEUTICA N.V. (BE) 2001-09-07 WO claimed
WO-2001064218-A2 FARNESYL PROTEIN TRANSFERASE INHIBITOR COMBINATIONS JANSSEN PHARMACEUTICA N.V. (BE) 2001-09-07 WO claimed
WO-2001064197-A2 FARNESYL PROTEIN TRANSFERASE INHIBITOR COMBINATIONS WITH ANTI-TUMOR ANTHRACYCLINE DERIVATIVES JANSSEN PHARMACEUTICA N.V. (BE) 2001-09-07 WO claimed
US-6251913-B1 Hydroxamic acids substituted by heterocycles useful for inhibition of tumor necrosis factor ZENECA LIMITED (GB) 2001-06-26 US claimed
EP-0971895-A1 HYDROXAMIC ACIDS SUBSTITUTED BY HETEROCYCLES USEFUL FOR INHIBITION OF TUMOR NECROSIS FACTOR AstraZeneca AB (SE) 2000-01-19 EP claimed
WO-1998043959-A1 HYDROXAMIC ACIDS SUBSTITUTED BY HETEROCYCLES USEFUL FOR INHIBITION OF TUMOR NECROSIS FACTOR ZENECA LIMITED (GB) 1998-10-08 WO claimed
US-5017636-A Also containing polyisoprene, natural rubber, butadiene-styrene copolymer, wear and heat resistance, resilience JAPAN SYNTHETIC RUBBER CO., LTD. (JP) 1991-05-21 US claimed
US-4822844-A MODIFIED WITH NITROGEN COMPOUND CONTAINING EITHER OXYGEN OR SULFUR AS BRANCHING OR END GROUP THE YOKOHAMA RUBBER CO., LTD. (JP) 1989-04-18 US claimed
US-4647625-A Process for modifying conjugated diene polymers NIPPON ZEON CO., LTD. (JP) 1987-03-03 US claimed
US-4616069-A REACTING THE ALKALI METAL OR ALKALINE EARTH METAL TERMINATED POLYMER WITH TIN COMPOUND AND ORGANIC COMPOUND HAVING AMIDE OR THIOAMIDE LINKAGES NIPPON ZEON CO., LTD. (JP) 1986-10-07 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260124198-A1 ANTIVIRAL PYRAZOLOPYRIDINONE COMPOUNDS ZC3HAV1, CCR1, CCR6 BRPF1 2763/4885BRD4 615/4885BRD9 909/4885
US-11286240-B2 Catalyst bound alpha radical and synthesis of OXO compounds using the same CBR1, POR, CAT BRPF1 956/4885BRD4 2021/4885BRD9 2851/4885
US-20160368906-A1 BICYCLIC HETEROCYCLIC DERIVATIVES AS BROMODOMAIN INHIBITORS BRD1, BRD2, BRD3 BRPF1 102/4885BRD4 4/4885BRD9 10/4885
US-20210147364-A1 A CATALYST BOUND ALPHA RADICAL AND SYNTHESIS OF OXO COMPOUNDS USING THE SAME CBR1, POR, CAT BRPF1 1021/4885BRD4 2064/4885BRD9 2757/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.