Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRPF1 | P55201 | 5/20 | 0.85 |
| ▸ | BRD4 | O60885 | 3/20 | 0.85 |
| ▸ | BRD9 | Q9H8M2 | 3/20 | 0.85 |
| ▸ | CA12 | O43570 | 2/20 | 0.85 |
| ▸ | CA9 | Q16790 | 2/20 | 0.85 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.85 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | DAO | P14920 | 1/20 | 0.49 |
| ▸ | BRD1 | O95696 | 2/20 | 0.47 |
| ▸ | BRPF3 | Q9ULD4 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | NQO2 | P16083 | 1/20 | 0.42 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL248619 | 0.92 | BRPF1 (1.00) | BRPF1BRD4BRD9CA12CA9 | |
| SCHEMBL29967380 | 0.92 | BRPF1 (1.00) | BRPF1BRD4BRD9CA12CA9 | |
| Hydrochloric Acid SCHEMBL30419636 | 0.90 | BRPF1 (0.96) | BRPF1BRD4BRD9CA12CA9 | |
| Hydrochloric Acid SCHEMBL1236989 | 0.90 | BRPF1 (0.96) | BRPF1BRD4BRD9CA12CA9 | |
| Hydrochloric Acid SCHEMBL7218030 | 0.88 | BRPF1 (0.92) | BRPF1BRD4BRD9CA12CA9 | |
| Pyridine SCHEMBL11505119 | 0.84 | BRPF1 (0.76) | BRPF1BRD4BRD9CA12CA9 | |
| SCHEMBL271495 | 0.75 | CA12 (0.63) | BRPF1BRD4BRD9CA12CA9 | |
| SCHEMBL6581393 | 0.74 | CA12 (0.52) | BRPF1BRD4BRD9CA12CA9 | |
| SCHEMBL26555542 | 0.74 | BRPF1 (0.68) | BRPF1BRD4BRD9CA12CA9 | |
| SCHEMBL31743122 | 0.74 | BRPF1 (0.61) | BRPF1BRD4BRD9CA12CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0073507-B1 | SULFONYL UREAS, PROCESS FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE | HOECHST AKTIENGESELLSCHAFT (DE) | 1985-10-16 | — | — | EP | disclosed |