SCHEMBL24862002

SCHEMBL24862002

CCC(=O)N[C@@H](C)c1ccc(C(=O)OC)cc1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ACACB O00763 2/20 0.52
ACACA Q13085 1/20 0.52
CNR1 P21554 1/20 0.50
CYP3A4 P08684 2/20 0.48
CYP2C9 P11712 2/20 0.48
CYP2C19 P33261 2/20 0.48
CYP2D6 P10635 1/20 0.48
ALDH1A1 P00352 3/20 0.48
LMNA P02545 2/20 0.48
KMT2A Q03164 2/20 0.47
MEN1 O00255 1/20 0.47
TAOK1 Q7L7X3 1/20 0.47
TAOK3 Q9H2K8 1/20 0.47
STAT3 P40763 1/20 0.47
GPR139 Q6DWJ6 2/20 0.47
MAPT P10636 3/20 0.46
TDP1 Q9NUW8 1/20 0.46
CA12 O43570 1/20 0.46
CA1 P00915 1/20 0.46
CA2 P00918 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12384758 0.86 ACACB (0.54) ACACBACACAALDH1A1KMT2AMEN1
SCHEMBL3713691 0.86 HTT (0.57) ACACBCYP3A4CYP2C9CYP2C19CYP2D6
SCHEMBL14553488 0.86 LOXL2 (0.51) ACACBCYP3A4CYP2C9CYP2C19CYP2D6
SCHEMBL23224329 0.86 GAA (0.53) CYP3A4CYP2C9CYP2C19CYP2D6ALDH1A1
SCHEMBL22060063 0.83 NR1H4 (0.56) ACACBACACACNR1ALDH1A1LMNA
SCHEMBL15918472 0.82 CNR1 (0.68) ACACBACACACNR1CYP3A4CYP2C19
SCHEMBL19413995 0.81 ACACB (0.56) ACACBACACAALDH1A1LMNAKMT2A
SCHEMBL14966445 0.81 ACACB (0.56) ACACBACACAALDH1A1LMNAKMT2A
SCHEMBL24835774 0.80 MAPT (0.49) CYP3A4CYP2C9CYP2C19CYP2D6ALDH1A1
SCHEMBL17583862 0.78 ACACB (0.66) ACACBACACACNR1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4116291-A1 SYNTHESIS OF NOVEL EP4 ANTAGONIST AND USE IN CANCERS AND INFLAMMATIONS Wuhan Humanwell Innovative Drug Research and Development Center Limited Company (CN) 2023-01-11 EP disclosed