Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Codeine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRD1 known ✓ | P41143 | 9/20 | 0.91 |
| ▸ | OPRM1 known ✓ | P35372 | 8/20 | 0.91 |
| ▸ | OPRK1 known ✓ | P41145 | 6/20 | 0.91 |
| ▸ | MRGPRX2 | Q96LB1 | 4/20 | 0.91 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.91 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.91 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.91 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.69 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.69 |
| ▸ | ARRB1 | P49407 | 1/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Codeine SCHEMBL38654010 | 1.00 | OPRD1 (0.91) | OPRD1OPRM1OPRK1MRGPRX2ADRB1 | |
| Codeine SCHEMBL10747292 | 1.00 | OPRD1 (0.91) | OPRD1OPRM1OPRK1MRGPRX2ADRB1 | |
| Codeine SCHEMBL24865 | 1.00 | OPRD1 (0.91) | OPRD1OPRM1OPRK1MRGPRX2ADRB1 | |
| Codeine SCHEMBL10747288 | 1.00 | OPRD1 (0.91) | OPRD1OPRM1OPRK1MRGPRX2ADRB1 | |
| Codeine SCHEMBL24863 | 1.00 | OPRD1 (0.91) | OPRD1OPRM1OPRK1MRGPRX2ADRB1 | |
| Codeine SCHEMBL3047133 | 0.99 | OPRM1 (0.91) | OPRD1OPRM1OPRK1MRGPRX2ADRB1 | |
| Codeine SCHEMBL3047135 | 0.99 | OPRM1 (0.91) | OPRD1OPRM1OPRK1MRGPRX2ADRB1 | |
| Codeine SCHEMBL7936660 | 0.97 | OPRD1 (0.86) | OPRD1OPRM1OPRK1MRGPRX2ADRB1 | |
| Codeine SCHEMBL3475282 | 0.97 | OPRD1 (0.89) | OPRD1OPRM1OPRK1MRGPRX2ADRB1 | |
| Codeine SCHEMBL156020 | 0.96 | OPRM1 (0.86) | OPRD1OPRM1OPRK1MRGPRX2ADRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 4082 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240282425-A1 | AUTHENTICATION METHODS AND SYSTEMS FOR DISPENSED PRESCRIPTIONS | LOW GORDON KEITH (US) | 2024-08-22 | — | — | US | claimed |
| EP-4327797-A2 | MULTI PHASE SOFT GEL CAPSULES, APPARATUS AND METHOD THEREOF | Catalent Ontario Limited (CA) | 2024-02-28 | — | — | EP | claimed |
| US-20240041777-A1 | PHARMACEUTICAL CAPSULE CONTAINING AT LEAST TWO TABLETS | RB HEALTH US LLC (US) | 2024-02-08 | — | — | US | claimed |
| WO-2023059810-A1 | STENTS AND METHODS OF USE | UNIVERSITY OF CONNECTICUT (US) | 2023-04-13 | — | — | WO | claimed |
| WO-2023044463-A1 | SILK FIBROIN DERIVED BRUSH-LIKE POLYMERS | UNIVERSITY OF CONNECTICUT (US) | 2023-03-23 | — | — | WO | claimed |
| US-20220142931-A1 | MULTIPHASE SOFT GEL CAPSULES, APPARATUS AND METHOD THEREOF | CATALENT ONTARIO LIMITED (CA) | 2022-05-12 | — | — | US | claimed |
| US-20220079937-A1 | PHARMACEUTICAL FORMULATION | RB HEALTH (US) LLC | 2022-03-17 | — | — | US | claimed |
| US-11173125-B2 | Multiphase soft gel capsules, apparatus and method thereof | CATALENT ONTARIO LIMITED (CA) | 2021-11-16 | — | — | US | claimed |
| US-20200261373-A1 | PHARMACEUTICAL CAPSULE CONTAINING AT LEAST TWO TABLETS | RECKITT BENCKISER LLC (US) | 2020-08-20 | — | — | US | claimed |
| WO-2019136355-A1 | COMPOSITIONS AND METHODS FOR PAIN MANAGEMENT | LOMED INC. (US) | 2019-07-11 | — | — | WO | claimed |
| WO-1985002542-A1 | ANALGESIC AND ANTI-INFLAMMATORY COMPOSITIONS COMPRISING XANTHINES AND METHODS OF USING SAME | SUNSHINE ABRAHAM | 1985-06-20 | — | — | WO | claimed |
| EP-0132472-A1 | Medicated products containing a magnesium trisilicate adsorbent with a medicament drug adsorbed thereon | WARNER-LAMBERT COMPANY (US) | 1985-02-13 | — | — | EP | claimed |
| US-4486436-A | Analgesic and anti-inflammatory compositions comprising caffeine and methods of using same | ANALGESIC ASSOCIATES (US) | 1984-12-04 | — | — | US | claimed |
| EP-0114886-A1 | IMPROVED ANALGESIC AND ANTI-INFLAMMATORY COMPOSITIONS COMPRISING CAFFEINE. | SUNSHINE ABRAHAM (US) | 1984-08-08 | — | — | EP | claimed |
| US-4464376-A | Analgesic and anti-inflammatory compositions comprising caffeine and methods of using same | RICHARDSON-VICKS, INC. (US) | 1984-08-07 | — | — | US | claimed |
| WO-1984000488-A1 | IMPROVED ANALGESIC AND ANTI-INFLAMMATORY COMPOSITIONS COMPRISING CAFFEINE AND METHODS OF USING SAME | RICHARDSON VICKS INC (US) | 1984-02-16 | — | — | WO | claimed |
| WO-1984000490-A1 | IMPROVED ANALGESIC AND ANTI-INFLAMMATORY COMPOSITIONS COMPRISING CAFFEINE AND METHODS OF USING SAME | SUNSHINE ABRAHAM | 1984-02-16 | — | — | WO | claimed |
| US-4369172-A | Prolonged release therapeutic compositions based on hydroxypropylmethylcellulose | FOREST LABORATORIES INC. (US) | 1983-01-18 | — | — | US | claimed |
| US-3992541-A | 2-(6-METHOXY-2-NAPHTHYL) PROPIONIC ACID | SYNTEX CORPORATION (PM) | 1976-11-16 | — | — | US | claimed |
| US-3936528-A | 2-(6-METHOXY-2-NAPHTHYL)PROPIONIC ACID OR SALT AND CODEINE OR PROPOXYPHENE | SYNTEX CORPORATION (US) | 1976-02-03 | — | — | US | claimed |