SCHEMBL24864800

SCHEMBL24864800

O=C(c1c(O)c2ccc3c4ccccc4sc3c2n(-c2ccc(-c3ccccc3)cc2)c1=O)C(F)(F)F

nearest known ligand 0.35

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
TP53 P04637 8/20 0.35
MAPT P10636 5/20 0.35
EGLN1 Q9GZT9 2/20 0.34
KMT2A Q03164 3/20 0.33
MEN1 O00255 2/20 0.33
HSP90AA1 P07900 1/20 0.33
RXFP1 Q9HBX9 3/20 0.33
POLB P06746 1/20 0.33
RECQL P46063 2/20 0.33
KDM4E B2RXH2 1/20 0.33
CYP1A2 P05177 1/20 0.33
CYP2C9 P11712 1/20 0.33
CYP2C19 P33261 1/20 0.33
HTT P42858 1/20 0.33
NPSR1 Q6W5P4 1/20 0.33
L3MBTL1 Q9Y468 1/20 0.33
PDE10A Q9Y233 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24864715 0.94 RECQL (0.37) TP53MAPTEGLN1KMT2AMEN1
SCHEMBL24865255 0.91 MAPT (0.36) TP53MAPTEGLN1KMT2AMEN1
SCHEMBL30171448 0.91 MAPT (0.36) TP53MAPTEGLN1KMT2AMEN1
SCHEMBL24864714 0.86 PARP14 (0.34) TP53MAPTEGLN1RXFP1POLB
SCHEMBL24864828 0.83 EGLN1 (0.33) TP53MAPTEGLN1RXFP1POLB
SCHEMBL24864719 0.81 ALDH1A1 (0.40) TP53MAPTEGLN1KMT2AMEN1
SCHEMBL24864991 0.81 RECQL (0.36) TP53MAPTEGLN1KMT2AMEN1
SCHEMBL30171422 0.81 RECQL (0.36) TP53MAPTEGLN1KMT2AMEN1
SCHEMBL24864826 0.80 TP53 (0.33) TP53MAPTRXFP1
SCHEMBL24864987 0.80 EGLN1 (0.32) EGLN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250074925-A1 RARE EARTH COMPLEX SAGAMI CHEMICAL RESEARCH INSTITUTE (JP) 2025-03-06 US disclosed
EP-4365180-A1 RARE EARTH COMPLEX Tosoh Corporation (JP) 2024-05-08 EP disclosed
WO-2023282236-A1 RARE EARTH COMPLEX 東ソー株式会社 2023-01-12 WO disclosed
WO-2023282236-A1 RARE EARTH COMPLEX 東ソー株式会社 2023-01-12 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250074925-A1 RARE EARTH COMPLEX L1CAM, CHRM1, NPM1 TP53 670/4885MAPT 3174/4885EGLN1 2861/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.